ENSMUSG00000022037


Mus musculus

Features
Gene ID: ENSMUSG00000022037
  
Biological name :Clu
  
Synonyms : Clu / Clusterin Clusterin beta chain Clusterin alpha chain / Q06890
  
Possible biological names infered from orthology : clusterin / P10909
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D1
Gene start: 65968483
Gene end: 65981547
  
Corresponding Affymetrix probe sets: 10416057 (MoGene1.0st)   1418626_a_at (Mouse Genome 430 2.0 Array)   1437458_x_at (Mouse Genome 430 2.0 Array)   1437689_x_at (Mouse Genome 430 2.0 Array)   1454849_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022616
Ensembl peptide - ENSMUSP00000121633
Ensembl peptide - ENSMUSP00000121485
Ensembl peptide - ENSMUSP00000121056
Ensembl peptide - ENSMUSP00000117953
Ensembl peptide - ENSMUSP00000117555
Ensembl peptide - ENSMUSP00000114720
NCBI entrez gene - 12759     See in Manteia.
MGI - MGI:88423
RefSeq - XM_006518504
RefSeq - NM_013492
RefSeq - XM_006518503
RefSeq Peptide - NP_038520
swissprot - D6RFP9
swissprot - E9Q8Y5
swissprot - E9Q9B8
swissprot - Q06890
swissprot - Q549A5
swissprot - E9Q2G2
swissprot - E9PUU2
swissprot - E9PXG5
Ensembl - ENSMUSG00000022037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cluENSDARG00000010434Danio rerio
 CLUENSGALG00000043051Gallus gallus
 CLUENSG00000120885Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000753  Clusterin-like
 IPR016014  Clusterin, N-terminal
 IPR016015  Clusterin, C-terminal
 IPR016016  Clusterin
 IPR027267  AH/BAR domain superfamily
 IPR033986  Clusterin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0017038 protein import IEA
 biological_processGO:0032286 central nervous system myelin maintenance IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032463 negative regulation of protein homooligomerization IEA
 biological_processGO:0032464 positive regulation of protein homooligomerization IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051131 chaperone-mediated protein complex assembly IEA
 biological_processGO:0051788 response to misfolded protein IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061077 chaperone-mediated protein folding IEA
 biological_processGO:0061518 microglial cell proliferation IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway ISS
 biological_processGO:1900221 regulation of amyloid-beta clearance IEA
 biological_processGO:1901214 regulation of neuron death IEA
 biological_processGO:1901216 positive regulation of neuron death IMP
 biological_processGO:1902004 positive regulation of amyloid-beta formation IMP
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:1902430 negative regulation of amyloid-beta formation IEA
 biological_processGO:1902847 regulation of neuronal signal transduction IEA
 biological_processGO:1902949 positive regulation of tau-protein kinase activity IEA
 biological_processGO:1902998 positive regulation of neurofibrillary tangle assembly IEA
 biological_processGO:1903573 negative regulation of response to endoplasmic reticulum stress IEA
 biological_processGO:1905892 negative regulation of cellular response to thapsigargin IEA
 biological_processGO:1905895 negative regulation of cellular response to tunicamycin IEA
 biological_processGO:1905907 negative regulation of amyloid fibril formation IEA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IEA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0034366 spherical high-density lipoprotein particle IEA
 cellular_componentGO:0042583 chromaffin granule IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:0097418 neurofibrillary tangle IEA
 cellular_componentGO:0097440 apical dendrite IEA
 cellular_componentGO:0106003 amyloid-beta complex IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IEA
 molecular_functionGO:0051787 misfolded protein binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Terminal pathway of complement
Antimicrobial peptides
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse,Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr5a2tm1Sjns/Nr5a2tm1Sjns,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Clutm1Jakh/Clutm1Jakh,Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Nr5a2tm1Sjns/Nr5a2tm1Sjns,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Clutm1Jakh/Clutm1Jakh,Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0005161 hematuria "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse,Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0005655 increased aggression "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Nr5a2tm1Sjns/Nr5a2tm1Sjns,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse,Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011338 abnormal mesangial matrix morphology "any structural anomaly of the extracellular matrix secreted by intraglomerular mesangial cells" [MGI:csmith]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse,Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse,Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse,Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse,Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse,Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0012270 cardiac edema "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse,Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse,Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035031 C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*  / reaction / complex
 ENSMUSG00000022149 C9 / complement C9 / P02748*  / reaction / complex
 ENSMUSG00000029656 C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*  / reaction / complex
 ENSMUSG00000022037 Clu / Q06890 / Clusterin Clusterin beta chain Clusterin alpha chain / P10909* / clusterin*  / complex
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction / complex
 ENSMUSG00000015083 C8g / Q8VCG4 / Complement component C8 gamma chain / P07360* / complement C8 gamma chain*  / reaction / complex
 ENSMUSG00000079105 C7 / complement component 7 / P10643* / complement C7*  / complex / reaction
 ENSMUSG00000022181 C6 / complement component 6 / P13671* / complement C6*  / complex / reaction
 ENSMUSG00000032496 Ltf / P08071 / Lactotransferrin / P02788*  / complex
 ENSMUSG00000017733 Eppin / Q9DA01 / O95925* / EPPIN-WFDC6* / EPPIN-WFDC6 readthrough* / epididymal peptidase inhibitor*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr