ENSMUSG00000032496


Mus musculus

Features
Gene ID: ENSMUSG00000032496
  
Biological name :Ltf
  
Synonyms : Lactotransferrin / Ltf / P08071
  
Possible biological names infered from orthology : P02788
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 111019271
Gene end: 111042767
  
Corresponding Affymetrix probe sets: 10589703 (MoGene1.0st)   1450009_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035077
Ensembl peptide - ENSMUSP00000143731
Ensembl peptide - ENSMUSP00000143629
Ensembl peptide - ENSMUSP00000143342
Ensembl peptide - ENSMUSP00000143234
Ensembl peptide - ENSMUSP00000142739
Ensembl peptide - ENSMUSP00000142691
Ensembl peptide - ENSMUSP00000142432
Ensembl peptide - ENSMUSP00000142403
NCBI entrez gene - 17002     See in Manteia.
MGI - MGI:96837
RefSeq - NM_008522
RefSeq Peptide - NP_032548
swissprot - A0A0G2JFM6
swissprot - A0A0G2JEE4
swissprot - A0A0G2JEA3
swissprot - A0A0G2JDN0
swissprot - A0A0G2JDK4
swissprot - A0A0G2JGX1
swissprot - P08071
swissprot - A0A0G2JGN1
swissprot - A0A0G2JFX4
Ensembl - ENSMUSG00000032496
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfaENSDARG00000016771Danio rerio
 TFENSGALG00000006453Gallus gallus
 LTFENSG00000012223Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trf / Q921I1 / Serotransferrin / TF* / P02787* / transferrin*ENSMUSG0000003255455
Q9DBD0 / 1300017J02Rik / RIKEN cDNA 1300017J02 geneENSMUSG0000003368854
Gm20425 / TF* / P02787* / transferrin*ENSMUSG0000009063953
Meltf / Q9R0R1 / Melanotransferrin / P08582*ENSMUSG0000002278039
Srprb / P47758 / Signal recognition particle receptor subunit beta ENSMUSG000000325531


Protein motifs (from Interpro)
Interpro ID Name
 IPR001156  Transferrin-like domain
 IPR016357  Transferrin
 IPR018195  Transferrin family, iron binding site
 IPR030684  Lactotransferrin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001817 regulation of cytokine production IEA
 biological_processGO:0002227 innate immune response in mucosa IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0019731 antibacterial humoral response IEA
 biological_processGO:0019732 antifungal humoral response IEA
 biological_processGO:0031640 killing of cells of other organism IEA
 biological_processGO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032680 regulation of tumor necrosis factor production IEA
 biological_processGO:0032780 negative regulation of ATPase activity IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0044793 negative regulation by host of viral process IEA
 biological_processGO:0045071 negative regulation of viral genome replication IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0048525 negative regulation of viral process IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051673 membrane disruption in other organism IEA
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0060349 bone morphogenesis IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1900159 positive regulation of bone mineralization involved in bone maturation ISS
 biological_processGO:1900229 negative regulation of single-species biofilm formation in or on host organism IEA
 biological_processGO:1902732 positive regulation of chondrocyte proliferation IEA
 biological_processGO:2000117 negative regulation of cysteine-type endopeptidase activity IEA
 biological_processGO:2000308 negative regulation of tumor necrosis factor (ligand) superfamily member 11 production ISS
 biological_processGO:2001205 negative regulation of osteoclast development ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042581 specific granule IEA
 cellular_componentGO:0044218 other organism cell membrane IEA
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Metal sequestration by antimicrobial proteins
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Mmp12tm1Sds/Mmp12tm1Sds
Genetic Background: involves: 129/Sv * 129T2/SvEms

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Mmp12tm1Sds/Mmp12tm1Sds
Genetic Background: involves: 129/Sv * 129T2/SvEms

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Mmp12tm1Sds/Mmp12tm1Sds
Genetic Background: involves: 129/Sv * 129T2/SvEms

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Mmp12tm1Sds/Mmp12tm1Sds
Genetic Background: involves: 129/Sv * 129T2/SvEms

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022037 Clu / Q06890 / Clusterin Clusterin beta chain Clusterin alpha chain / P10909* / clusterin*  / complex
 ENSMUSG00000017733 Eppin / Q9DA01 / O95925* / EPPIN-WFDC6* / EPPIN-WFDC6 readthrough* / epididymal peptidase inhibitor*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr