ENSMUSG00000032554


Mus musculus

Features
Gene ID: ENSMUSG00000032554
  
Biological name :Trf
  
Synonyms : Q921I1 / Serotransferrin / Trf
  
Possible biological names infered from orthology : P02787 / TF / transferrin
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 103204001
Gene end: 103230444
  
Corresponding Affymetrix probe sets: 10596148 (MoGene1.0st)   1425546_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128390
Ensembl peptide - ENSMUSP00000129013
Ensembl peptide - ENSMUSP00000128647
Ensembl peptide - ENSMUSP00000128609
Ensembl peptide - ENSMUSP00000035158
Ensembl peptide - ENSMUSP00000108264
Ensembl peptide - ENSMUSP00000120472
NCBI entrez gene - 22041     See in Manteia.
MGI - MGI:98821
RefSeq - NM_133977
RefSeq Peptide - NP_598738
swissprot - F7BAE9
swissprot - F7CJN9
swissprot - E9Q939
swissprot - Q921I1
swissprot - E9Q2Q7
swissprot - D3YYR8
Ensembl - ENSMUSG00000032554
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfaENSDARG00000016771Danio rerio
 TFENSGALG00000006453Gallus gallus
 TFENSG00000091513Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm20425 / TF* / P02787* / transferrin*ENSMUSG0000009063997
Q9DBD0 / 1300017J02Rik / RIKEN cDNA 1300017J02 geneENSMUSG0000003368859
Ltf / P08071 / Lactotransferrin / P02788*ENSMUSG0000003249656
Meltf / Q9R0R1 / Melanotransferrin / P08582*ENSMUSG0000002278038
Srprb / P47758 / Signal recognition particle receptor subunit beta ENSMUSG000000325531


Protein motifs (from Interpro)
Interpro ID Name
 IPR001156  Transferrin-like domain
 IPR016357  Transferrin
 IPR018195  Transferrin family, iron binding site
 IPR029785  Inhibitor of carbonic anhydrase
 IPR030685  Serotransferrin, mammalian


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006826 iron ion transport IMP
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0007015 actin filament organization IDA
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0015682 ferric iron transport IEA
 biological_processGO:0030316 osteoclast differentiation IDA
 biological_processGO:0042327 positive regulation of phosphorylation IDA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045780 positive regulation of bone resorption IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis ISO
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0070371 ERK1 and ERK2 cascade IDA
 biological_processGO:0071281 cellular response to iron ion ISO
 biological_processGO:0098707 ferrous iron import across plasma membrane ISO
 biological_processGO:2000147 positive regulation of cell motility IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005770 late endosome ISO
 cellular_componentGO:0005905 clathrin-coated pit ISO
 cellular_componentGO:0009925 basal plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IMP
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0030120 vesicle coat ISO
 cellular_componentGO:0030139 endocytic vesicle ISO
 cellular_componentGO:0031232 extrinsic component of external side of plasma membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0045178 basal part of cell ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0055037 recycling endosome ISO
 cellular_componentGO:0097433 dense body ISO
 cellular_componentGO:1990712 HFE-transferrin receptor complex ISO
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008198 ferrous iron binding ISO
 molecular_functionGO:0008199 ferric iron binding IEA
 molecular_functionGO:0015091 ferric iron transmembrane transporter activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990459 transferrin receptor binding ISO


Pathways (from Reactome)
Pathway description
Platelet degranulation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Post-translational protein phosphorylation
Iron uptake and transport
Transferrin endocytosis and recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002424 abnormal reticulocyte morphology/development "anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0005638 hemochromatosis "disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:64456]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008387 hypochromic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022797 Tfrc / Q62351 / transferrin receptor / P02786*  / complex / reaction
 ENSMUSG00000032554 Trf / Q921I1 / Serotransferrin / TF* / P02787* / transferrin*  / reaction / complex
 ENSMUSG00000029716 Tfr2 / Q9JKX3 / Transferrin receptor protein 2 / Q9UP52* / transferrin receptor 2*  / reaction / complex






 

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