ENSG00000012223


Homo sapiens

Features
Gene ID: ENSG00000012223
  
Biological name :LTF
  
Synonyms : lactotransferrin / LTF / P02788
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 46435645
Gene end: 46485234
  
Corresponding Affymetrix probe sets: 202018_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000405719
Ensembl peptide - ENSP00000231751
Ensembl peptide - ENSP00000395234
Ensembl peptide - ENSP00000397427
Ensembl peptide - ENSP00000405546
NCBI entrez gene - 4057     See in Manteia.
OMIM - 150210
RefSeq - NM_001199149
RefSeq - NM_001321121
RefSeq - NM_001321122
RefSeq - NM_002343
RefSeq Peptide - NP_002334
RefSeq Peptide - NP_001186078
RefSeq Peptide - NP_001308050
RefSeq Peptide - NP_001308051
swissprot - E7EQB2
swissprot - C9JCF5
swissprot - P02788
swissprot - V9HWI4
swissprot - E7ER44
Ensembl - ENSG00000012223
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfaENSDARG00000016771Danio rerio
 TFENSGALG00000006453Gallus gallus
 LtfENSMUSG00000032496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TF / P02787 / transferrinENSG0000009151360
MELTF / P08582 / melanotransferrinENSG0000016397540


Protein motifs (from Interpro)
Interpro ID Name
 IPR001156  Transferrin-like domain
 IPR016357  Transferrin
 IPR018195  Transferrin family, iron binding site
 IPR030684  Lactotransferrin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001817 regulation of cytokine production IEA
 biological_processGO:0001895 retina homeostasis HEP
 biological_processGO:0002227 innate immune response in mucosa IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006959 humoral immune response TAS
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0019731 antibacterial humoral response IEA
 biological_processGO:0019732 antifungal humoral response IEA
 biological_processGO:0031640 killing of cells of other organism IMP
 biological_processGO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032680 regulation of tumor necrosis factor production IDA
 biological_processGO:0032780 negative regulation of ATPase activity IMP
 biological_processGO:0033214 iron assimilation by chelation and transport TAS
 biological_processGO:0033690 positive regulation of osteoblast proliferation IDA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IMP
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0044793 negative regulation by host of viral process IMP
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0048525 negative regulation of viral process IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051673 membrane disruption in other organism IMP
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0060349 bone morphogenesis IDA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IDA
 biological_processGO:1900159 positive regulation of bone mineralization involved in bone maturation ISS
 biological_processGO:1900229 negative regulation of single-species biofilm formation in or on host organism IDA
 biological_processGO:1902732 positive regulation of chondrocyte proliferation IDA
 biological_processGO:2000117 negative regulation of cysteine-type endopeptidase activity IDA
 biological_processGO:2000308 negative regulation of tumor necrosis factor (ligand) superfamily member 11 production ISS
 biological_processGO:2001205 negative regulation of osteoclast development ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0042581 specific granule IDA
 cellular_componentGO:0044218 other organism cell membrane IMP
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097013 phagocytic vesicle lumen TAS
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0001530 lipopolysaccharide binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Mtb iron assimilation by chelation
Neutrophil degranulation
Metal sequestration by antimicrobial proteins
Antimicrobial peptides
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000012223 LTF / P02788 / lactotransferrin  / -
 ENSG00000124233 SEMG1 / P04279 / semenogelin I  / complex
 ENSG00000101448 EPPIN / O95925 / epididymal peptidase inhibitor  / complex
 ENSG00000120885 CLU / P10909 / clusterin  / complex






 

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