ENSGALG00000043051


Gallus gallus

Features
Gene ID: ENSGALG00000043051
  
Biological name :CLU
  
Synonyms : CLU / clusterin precursor
  
Possible biological names infered from orthology : clusterin / Clusterin Clusterin beta chain Clusterin alpha chain / P10909 / Q06890
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 105644982
Gene end: 105652231
  
Corresponding Affymetrix probe sets: Gga.423.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046664
Ensembl peptide - ENSGALP00000054300
NCBI entrez gene - 395722     See in Manteia.
RefSeq - XM_015285089
RefSeq - NM_204900
RefSeq - XM_015285087
RefSeq - XM_015285088
RefSeq Peptide - NP_990231
swissprot - A0A1D5PN61
swissprot - A0A1D5P1X2
Ensembl - ENSGALG00000043051
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cluENSDARG00000010434Danio rerio
 CLUENSG00000120885Homo sapiens
 CluENSMUSG00000022037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLUL1 / clusterin like 1 / Q15846*ENSGALG0000001490423


Protein motifs (from Interpro)
Interpro ID Name
 IPR000753  Clusterin-like
 IPR016014  Clusterin, N-terminal
 IPR016015  Clusterin, C-terminal
 IPR016016  Clusterin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0017038 protein import IEA
 biological_processGO:0032286 central nervous system myelin maintenance IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032463 negative regulation of protein homooligomerization IEA
 biological_processGO:0032464 positive regulation of protein homooligomerization IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051131 chaperone-mediated protein complex assembly IEA
 biological_processGO:0051788 response to misfolded protein IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061077 chaperone-mediated protein folding IEA
 biological_processGO:0061518 microglial cell proliferation IEA
 biological_processGO:1900221 regulation of amyloid-beta clearance IEA
 biological_processGO:1901214 regulation of neuron death IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:1902430 negative regulation of amyloid-beta formation IEA
 biological_processGO:1902847 regulation of neuronal signal transduction IEA
 biological_processGO:1902949 positive regulation of tau-protein kinase activity IEA
 biological_processGO:1902998 positive regulation of neurofibrillary tangle assembly IEA
 biological_processGO:1903573 negative regulation of response to endoplasmic reticulum stress IEA
 biological_processGO:1905892 negative regulation of cellular response to thapsigargin IEA
 biological_processGO:1905895 negative regulation of cellular response to tunicamycin IEA
 biological_processGO:1905907 negative regulation of amyloid fibril formation IEA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0034366 spherical high-density lipoprotein particle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:0097418 neurofibrillary tangle IEA
 cellular_componentGO:0097440 apical dendrite IEA
 cellular_componentGO:0106003 amyloid-beta complex IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IEA
 molecular_functionGO:0051787 misfolded protein binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Terminal pathway of complement
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001565 C5 / complement C5 / Hc* / P01031* / P06684* / hemolytic complement*  / complex / reaction
 ENSGALG00000014840 C6 / complement C6 / P13671* / complement component 6*  / reaction / complex
 ENSGALG00000010850 C8A / complement C8 alpha chain / P07357* / Q8K182* / Complement component C8 alpha chain *  / reaction / complex
 ENSGALG00000010853 C8B / Gallus gallus complement C8 beta chain (C8B), mRNA. / P07358* / Q8BH35* / complement C8 beta chain* / Complement component C8 beta chain *  / reaction / complex
 ENSGALG00000043051 CLU / clusterin precursor / P10909* / Q06890* / clusterin* / Clusterin Clusterin beta chain Clusterin alpha chain*  / complex






 

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