ENSGALG00000001565


Gallus gallus

Features
Gene ID: ENSGALG00000001565
  
Biological name :C5
  
Synonyms : C5 / complement C5
  
Possible biological names infered from orthology : Hc / hemolytic complement / P01031 / P06684
  
Species: Gallus gallus
  
Chr. number: 17
Strand: -1
Band:
Gene start: 8801959
Gene end: 8828360
  
Corresponding Affymetrix probe sets: GgaAffx.1020.1.S1_s_at (Chicken Array)   GgaAffx.1020.4.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002377
Ensembl peptide - ENSGALP00000050742
Ensembl peptide - ENSGALP00000050353
NCBI entrez gene - 417122     See in Manteia.
RefSeq - XM_415405
swissprot - E1BRS7
swissprot - A0A1D5PD98
swissprot - A0A1D5PC67
Ensembl - ENSGALG00000001565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c5ENSDARG00000021004Danio rerio
 C5ENSG00000106804Homo sapiens
 HcENSMUSG00000026874Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000001704027
C4 / complement 4 precursor / C4A* / C4B* / P0C0L5* / P01029* / P0C0L4* / complement C4B (Chido blood group)* / complement C4A (Rodgers blood group)* / Complement C4-B Complement C4 beta c...ENSGALG0000003223124
CD109 / CD109 molecule / Q6YHK3* / Q8R422* / CD109 antigen *ENSGALG0000001591019
ENSGALG0000000029318
OVST / ovostatin precursor / A2ml1* / Q3UU35* / alpha-2-macroglobulin like 1*ENSGALG0000001193017
A2ML1 / alpha-2-macroglobulin like 1 / A8K2U0*ENSGALG0000003644717
PZP* / A2M* / Mug2* / Mug1* / Q6GQT1* / Gm7298* / P01023* / P20742* / P28665* / P28666* / Q61838* / Murinoglobulin-2 * / Murinoglobulin-1 * / alpha-2-macroglobulin* / PZP, alpha-2-macroglob...ENSGALG0000003976416
ENSGALG0000001425215
CPAMD8 / C3 and PZP like, alpha-2-macroglobulin domain containing 8 / Q8IZJ3*ENSGALG0000000374214
PZP* / A2M* / Mug2* / Mug1* / Q6GQT1* / Gm7298* / P01023* / P20742* / P28665* / P28666* / Q61838* / Murinoglobulin-2 * / Murinoglobulin-1 * / alpha-2-macroglobulin* / PZP, alpha-2-macroglob...ENSGALG0000003165912


Protein motifs (from Interpro)
Interpro ID Name
 IPR000020  Anaphylatoxin/fibulin
 IPR001134  Netrin domain
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR018081  Anaphylatoxin, complement system
 IPR018933  Netrin module, non-TIMP type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010760 negative regulation of macrophage chemotaxis IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0090197 positive regulation of chemokine secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005579 membrane attack complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Terminal pathway of complement
Activation of C3 and C5
G alpha (i) signalling events
Regulation of Complement cascade
Formation of membrane attack complex (MAC)
Regulation of complement cascades
Complement Cascade
Anaphylatoxins initiate inflammatory responses


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014840 C6 / complement C6 / P13671* / complement component 6*  / reaction / complex
 ENSGALG00000043051 CLU / clusterin precursor / P10909* / Q06890* / clusterin* / Clusterin Clusterin beta chain Clusterin alpha chain*  / reaction / complex
 ENSGALG00000010850 C8A / complement C8 alpha chain / P07357* / Q8K182* / Complement component C8 alpha chain *  / reaction / complex
 ENSGALG00000010853 C8B / Gallus gallus complement C8 beta chain (C8B), mRNA. / P07358* / Q8BH35* / complement C8 beta chain* / Complement component C8 beta chain *  / reaction / complex
 ENSGALG00000001565 C5 / complement C5 / Hc* / P01031* / P06684* / hemolytic complement*  / complex
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSGALG00000007090 CPN1 / carboxypeptidase N subunit 1 / P15169* / Q9JJN5* / carboxypeptidase N, polypeptide 1*  / reaction






 

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