ENSGALG00000032231


Gallus gallus

Features
Gene ID: ENSGALG00000032231
  
Biological name :C4
  
Synonyms : C4 / complement 4 precursor
  
Possible biological names infered from orthology : C4A / C4B / complement C4A (Rodgers blood group) / complement C4B (Chido blood group) / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / P01029 / P0C0L4 / P0C0L5
  
Species: Gallus gallus
  
Chr. number: 16
Strand: -1
Band:
Gene start: 58543
Gene end: 72898
  
Corresponding Affymetrix probe sets: Gga.16394.1.S1_at (Chicken Array)   Gga.16663.1.A1_at (Chicken Array)   Gga.16663.1.S1_at (Chicken Array)   Gga.16663.1.S1_s_at (Chicken Array)   GgaAffx.24460.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048078
Ensembl peptide - ENSGALP00000064803
Ensembl peptide - ENSGALP00000054007
NCBI entrez gene - 426611     See in Manteia.
RefSeq - NM_001077233
RefSeq Peptide - NP_001070701
swissprot - A0A1L1S0Z4
swissprot - A0A1D5PMD0
swissprot - A0A1D5P5V5
Ensembl - ENSGALG00000032231
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 C4AENSG00000244731Homo sapiens
 C4BENSG00000224389Homo sapiens
 C4bENSMUSG00000073418Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000001704030
C5 / complement C5 / Hc* / P01031* / P06684* / hemolytic complement*ENSGALG0000000156524
ENSGALG0000000029318
OVST / ovostatin precursor / A2ml1* / Q3UU35* / alpha-2-macroglobulin like 1*ENSGALG0000001193017
PZP* / A2M* / Mug2* / Mug1* / Q6GQT1* / Gm7298* / P01023* / P20742* / P28665* / P28666* / Q61838* / Murinoglobulin-2 * / Murinoglobulin-1 * / alpha-2-macroglobulin* / PZP, alpha-2-macroglob...ENSGALG0000003976416
CD109 / CD109 molecule / Q6YHK3* / Q8R422* / CD109 antigen *ENSGALG0000001591016
ENSGALG0000001425215
A2ML1 / alpha-2-macroglobulin like 1 / A8K2U0*ENSGALG0000003644715
CPAMD8 / C3 and PZP like, alpha-2-macroglobulin domain containing 8 / Q8IZJ3*ENSGALG0000000374214
PZP* / A2M* / Mug2* / Mug1* / Q6GQT1* / Gm7298* / P01023* / P20742* / P28665* / P28666* / Q61838* / Murinoglobulin-2 * / Murinoglobulin-1 * / alpha-2-macroglobulin* / PZP, alpha-2-macroglob...ENSGALG0000003165911


Protein motifs (from Interpro)
Interpro ID Name
 IPR000020  Anaphylatoxin/fibulin
 IPR001134  Netrin domain
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR018081  Anaphylatoxin, complement system
 IPR018933  Netrin module, non-TIMP type
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Activation of C3 and C5
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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