ENSMUSG00000022181


Mus musculus

Features
Gene ID: ENSMUSG00000022181
  
Biological name :C6
  
Synonyms : C6 / complement component 6
  
Possible biological names infered from orthology : complement C6 / P13671
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 4727175
Gene end: 4814967
  
Corresponding Affymetrix probe sets: 10422635 (MoGene1.0st)   1449308_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022788
Ensembl peptide - ENSMUSP00000124417
Ensembl peptide - ENSMUSP00000125358
Ensembl peptide - ENSMUSP00000125693
NCBI entrez gene - 12274     See in Manteia.
MGI - MGI:88233
RefSeq - XM_006519959
RefSeq - NM_016704
RefSeq - XM_006519957
RefSeq - XM_006519958
RefSeq Peptide - NP_057913
swissprot - Q91X70
swissprot - E9Q6D8
swissprot - Q8BRY4
Ensembl - ENSMUSG00000022181
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c6ENSDARG00000057113Danio rerio
 c6ENSDARG00000093052Danio rerio
 C6ENSGALG00000014840Gallus gallus
 C6ENSG00000039537Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C7 / complement component 7 / P10643* / complement C7*ENSMUSG0000007910527
C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*ENSMUSG0000003503123
C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*ENSMUSG0000002965621
C9 / complement C9 / P02748*ENSMUSG0000002214917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001862  Membrane attack complex component/perforin/complement C9
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR002350  Kazal domain
 IPR003884  Factor I / membrane attack complex
 IPR020863  Membrane attack complex component/perforin domain, conserved site
 IPR020864  Membrane attack complex component/perforin (MACPF) domain
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036055  LDL receptor-like superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily
 IPR037563  Complement component C6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001970 positive regulation of activation of membrane attack complex IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006956 complement activation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045917 positive regulation of complement activation IMP
 cellular_componentGO:0005579 membrane attack complex ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Terminal pathway of complement
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Disc1del/Disc1del
Genetic Background: B6.129S6-Disc1del

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129 * 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015083 C8g / Q8VCG4 / Complement component C8 gamma chain / P07360* / complement C8 gamma chain*  / complex / reaction
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / complex / reaction
 ENSMUSG00000022037 Clu / Q06890 / Clusterin Clusterin beta chain Clusterin alpha chain / P10909* / clusterin*  / complex / reaction
 ENSMUSG00000022149 C9 / complement C9 / P02748*  / reaction / complex
 ENSMUSG00000079105 C7 / complement component 7 / P10643* / complement C7*  / reaction / complex
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / complex / reaction
 ENSMUSG00000032679 Cd59a / O55186 / CD59A glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / complex / reaction
 ENSMUSG00000068686 Cd59b / P58019 / CD59B glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / reaction / complex
 ENSMUSG00000029656 C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*  / reaction / complex
 ENSMUSG00000035031 C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*  / reaction / complex






 

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