ENSMUSG00000022149


Mus musculus

Features
Gene ID: ENSMUSG00000022149
  
Biological name :C9
  
Synonyms : C9 / complement C9
  
Possible biological names infered from orthology : P02748
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 6445327
Gene end: 6498751
  
Corresponding Affymetrix probe sets: 10422748 (MoGene1.0st)   1422815_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022749
Ensembl peptide - ENSMUSP00000135459
Ensembl peptide - ENSMUSP00000135614
NCBI entrez gene - 12279     See in Manteia.
MGI - MGI:1098282
RefSeq - NM_013485
RefSeq Peptide - NP_038513
swissprot - H3BL17
swissprot - H3BKN4
swissprot - A0A0R4J032
Ensembl - ENSMUSG00000022149
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c9ENSDARG00000016319Danio rerio
 C9ENSG00000113600Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*ENSMUSG0000003503129
C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*ENSMUSG0000002965627
C7 / complement component 7 / P10643* / complement C7*ENSMUSG0000007910523
C6 / complement component 6 / P13671* / complement C6*ENSMUSG0000002218123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001862  Membrane attack complex component/perforin/complement C9
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR020863  Membrane attack complex component/perforin domain, conserved site
 IPR020864  Membrane attack complex component/perforin (MACPF) domain
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR036055  LDL receptor-like superfamily
 IPR037567  Complement component C9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001906 cell killing IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0051260 protein homooligomerization IEA
 cellular_componentGO:0005579 membrane attack complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Terminal pathway of complement
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0005385 cardiovascular system phenotype 
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0010507 shortened RR interval "reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015083 C8g / Q8VCG4 / Complement component C8 gamma chain / P07360* / complement C8 gamma chain*  / reaction / complex
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction / complex
 ENSMUSG00000022037 Clu / Q06890 / Clusterin Clusterin beta chain Clusterin alpha chain / P10909* / clusterin*  / complex / reaction
 ENSMUSG00000079105 C7 / complement component 7 / P10643* / complement C7*  / complex / reaction
 ENSMUSG00000022181 C6 / complement component 6 / P13671* / complement C6*  / complex / reaction
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / complex / reaction
 ENSMUSG00000032679 Cd59a / O55186 / CD59A glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / reaction / complex
 ENSMUSG00000068686 Cd59b / P58019 / CD59B glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / reaction / complex
 ENSMUSG00000022149 C9 / complement C9 / P02748*  / reaction
 ENSMUSG00000029656 C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*  / complex / reaction
 ENSMUSG00000035031 C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*  / reaction / complex






 

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