ENSDARG00000036041


Danio rerio

Features
Gene ID: ENSDARG00000036041
  
Biological name :f2
  
Synonyms : coagulation factor II (thrombin) / f2
  
Possible biological names infered from orthology : P00734 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 38750871
Gene end: 38760158
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000052324
Ensembl peptide - ENSDARP00000142823
Ensembl peptide - ENSDARP00000104071
NCBI entrez gene - 325881     See in Manteia.
RefSeq - NM_213390
RefSeq - XM_005168965
RefSeq Peptide - NP_998555
swissprot - F1R704
swissprot - E7FAN5
swissprot - A0A1D5NSK6
ZFIN ID - ZDB-GENE-030131-4606
Ensembl - ENSDARG00000036041
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F2ENSGALG00000008332Gallus gallus
 F2ENSG00000180210Homo sapiens
 F2ENSMUSG00000027249Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plg / plasminogen / LPA* / P08519* / P20918* / P00747* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*ENSDARG0000002311127
hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*ENSDARG0000004554423
mst1 / macrophage stimulating 1 / P26928* / macrophage stimulating 1 (hepatocyte growth factor-like)*ENSDARG0000010330821
hgfb / hepatocyte growth factor b / HGF* / P14210* / hepatocyte growth factor*ENSDARG0000007907621
habp2 / hyaluronan binding protein 2 / Q14520* / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA.*ENSDARG0000005749820
plat / plasminogen activator, tissue / P11214* / P00750* / plasminogen activator, tissue type* / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plas...ENSDARG0000006270718
plaub / plasminogen activator, urokinase b / PLAU* / P00749* / P06869* / plasminogen activator, urokinase*ENSDARG0000003914518
plaua / plasminogen activator, urokinase a / PLAU* / P00749* / P06869* / plasminogen activator, urokinase*ENSDARG0000007526515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR003966  Prothrombin/thrombin
 IPR009003  Peptidase S1, PA clan
 IPR013806  Kringle-like fold
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018056  Kringle, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR018992  Thrombin light chain
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007596 blood coagulation IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity NAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000021208 serpind1 / serpin peptidase inhibitor, clade D (heparin cofactor), member 1 / P05546* / P49182* / serpin family D member 1* / serine (or cysteine) peptidase inhibitor, clade D, member 1*  / complex / reaction
 ENSDARG00000055705 f5 / coagulation factor V / O88783* / P12259* / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain*  / reaction
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / reaction
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / reaction
 ENSDARG00000094132 igf1 / insulin-like growth factor 1 / P05017* / P05019* / Insulin-like growth factor I *  / reaction
 ENSDARG00000029353 serpine2 / serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 / P07093* / serpin family E member 2*  / complex / reaction
 ENSDARG00000099144 igfbp3 / insulin-like growth factor binding protein 3 / P17936* / P47878*  / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / complex
 ENSDARG00000060012 f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *  / reaction / complex
 ENSDARG00000037836 igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction
 ENSDARG00000033307 igf2b / insulin-like growth factor 2b / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / reaction
 ENSDARG00000079472 CABZ01071020.1 / F2RL2* / O00254* / coagulation factor II thrombin receptor like 2*  / reaction / complex
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / reaction
 ENSDARG00000077231 vwf / von Willebrand factor / P04275*  / reaction
 ENSDARG00000042684 serpinc1 / serpin peptidase inhibitor, clade C (antithrombin), member 1 / P01008* / P32261* / serpin family C member 1* / serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1*  / complex / reaction
 ENSDARG00000021004 c5 / complement component 5 / P01031* / complement C5*  / reaction
 ENSDARG00000090524 f2rl2 / coagulation factor II (thrombin) receptor-like 2 / O00254*  / reaction / complex
 ENSDARG00000079399 F2RL3 / si:ch211-132p1.2 / O88634* / Q96RI0* / Proteinase-activated receptor 4 * / F2R like thrombin or trypsin receptor 3*  / reaction / complex
 ENSDARG00000062909 furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000077540 f2rl1.2 / coagulation factor II (thrombin) receptor-like 1, tandem duplicate 2 / F2RL1* / P55086* / P55085* / F2R like trypsin receptor 1* / Proteinase-activated receptor 2 *  / complex / reaction
 ENSDARG00000068856 f2rl1.1 / coagulation factor II (thrombin) receptor-like 1, tandem duplicate 1 / F2RL1* / P55086* / P55085* / F2R like trypsin receptor 1* / Proteinase-activated receptor 2 *  / complex / reaction
 ENSDARG00000070971 furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000088581 f10 / coagulation factor X / O88947* / P00742* / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain*  / reaction






 

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