ENSDARG00000079076


Danio rerio

Features
Gene ID: ENSDARG00000079076
  
Biological name :hgfb
  
Synonyms : hepatocyte growth factor b / hgfb
  
Possible biological names infered from orthology : hepatocyte growth factor / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / HGF / P14210 / Q08048
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 9996813
Gene end: 10062630
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000101310
swissprot - F6PA78
ZFIN ID - ZDB-GENE-041014-3
Ensembl - ENSDARG00000079076
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HGFENSGALG00000033974Gallus gallus
 HGFENSG00000019991Homo sapiens
 HgfENSMUSG00000028864Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*ENSDARG0000004554459
mst1 / macrophage stimulating 1 / P26928* / macrophage stimulating 1 (hepatocyte growth factor-like)*ENSDARG0000010330841
plg / plasminogen / LPA* / P08519* / P20918* / P00747* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*ENSDARG0000002311137
f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*ENSDARG0000003604120
habp2 / hyaluronan binding protein 2 / Q14520* / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA.*ENSDARG0000005749817
plat / plasminogen activator, tissue / P11214* / P00750* / plasminogen activator, tissue type* / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plas...ENSDARG0000006270715
plaub / plasminogen activator, urokinase b / PLAU* / P00749* / P06869* / plasminogen activator, urokinase*ENSDARG0000003914514
plaua / plasminogen activator, urokinase a / PLAU* / P00749* / P06869* / plasminogen activator, urokinase*ENSDARG0000007526512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR003609  PAN/Apple domain
 IPR009003  Peptidase S1, PA clan
 IPR013806  Kringle-like fold
 IPR018056  Kringle, conserved site
 IPR024174  Hepatocyte growth factor-like
 IPR027284  Hepatocyte growth factor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0021549 cerebellum development IGI
 biological_processGO:0021587 cerebellum morphogenesis IGI
 biological_processGO:0021707 cerebellar granule cell differentiation IGI
 biological_processGO:0021953 central nervous system neuron differentiation IGI
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
PIP3 activates AKT signaling
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
NTRK2 activates RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000100 cerebellum cerebellum neuron decreased amount , abnormal
cerebellum cerebellar granule cell decreased amount , abnormal
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 ZFA:0000123 liver liver morphology , abnormal
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 ZFA:0000140 pancreas pancreas spheroid , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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