ENSDARG00000023111


Danio rerio

Features
Gene ID: ENSDARG00000023111
  
Biological name :plg
  
Synonyms : plasminogen / plg
  
Possible biological names infered from orthology : lipoprotein(a) / LPA / P00747 / P08519 / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 42688488
Gene end: 42702884
  
Corresponding Affymetrix probe sets: Dr.20821.1.A1_at (Zebrafish Array)   Dr.3645.1.S1_at (Zebrafish Array)   NM_201472_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000045815
Ensembl peptide - ENSDARP00000115432
NCBI entrez gene - 322691     See in Manteia.
RefSeq - NM_201472
RefSeq Peptide - NP_958880
swissprot - F1Q890
swissprot - E9QGF2
ZFIN ID - ZDB-GENE-030131-1411
Ensembl - ENSDARG00000023111
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000028886Gallus gallus
 ENSGALG00000004293Gallus gallus
 LPAENSG00000198670Homo sapiens
 PLGENSG00000122194Homo sapiens
 PlgENSMUSG00000059481Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mst1 / macrophage stimulating 1 / P26928* / macrophage stimulating 1 (hepatocyte growth factor-like)*ENSDARG0000010330834
hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*ENSDARG0000004554432
hgfb / hepatocyte growth factor b / HGF* / P14210* / hepatocyte growth factor*ENSDARG0000007907631
f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*ENSDARG0000003604121
habp2 / hyaluronan binding protein 2 / Q14520* / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA.*ENSDARG0000005749820
plat / plasminogen activator, tissue / P11214* / P00750* / plasminogen activator, tissue type* / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plas...ENSDARG0000006270719
plaua / plasminogen activator, urokinase a / PLAU* / P00749* / P06869* / plasminogen activator, urokinase*ENSDARG0000007526514
plaub / plasminogen activator, urokinase b / PLAU* / P00749* / P06869* / plasminogen activator, urokinase*ENSDARG0000003914514


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR003609  PAN/Apple domain
 IPR009003  Peptidase S1, PA clan
 IPR013806  Kringle-like fold
 IPR018056  Kringle, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR023317  Peptidase S1A, plasmin
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0048771 tissue remodeling IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Signaling by PDGF
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Dissolution of Fibrin Clot
LDL remodeling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000077588 pdgfc / platelet derived growth factor c / Q8CI19* / Q9NRA1* / platelet-derived growth factor, C polypeptide*  / reaction
 ENSDARG00000099144 igfbp3 / insulin-like growth factor binding protein 3 / P17936* / P47878*  / reaction
 ENSDARG00000037836 igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction
 ENSDARG00000023111 plg / plasminogen / LPA* / P08519* / P20918* / P00747* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / complex
 ENSDARG00000033307 igf2b / insulin-like growth factor 2b / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / reaction
 ENSDARG00000062707 plat / plasminogen activator, tissue / P11214* / P00750* / plasminogen activator, tissue type* / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plas...  / reaction / complex
 ENSDARG00000094132 igf1 / insulin-like growth factor 1 / P05017* / P05019* / Insulin-like growth factor I *  / reaction
 ENSDARG00000076448 serpinf2a / serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a / Q61247* / P08697* / SERPINF2* / serpin family F member 2* / serine (or ...  / reaction / complex






 

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