ENSDARG00000094132


Danio rerio

Features
Gene ID: ENSDARG00000094132
  
Biological name :igf1
  
Synonyms : igf1 / insulin-like growth factor 1
  
Possible biological names infered from orthology : Insulin-like growth factor I / P05017 / P05019
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 17310143
Gene end: 17326717
  
Corresponding Affymetrix probe sets: Dr.12402.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000017449
NCBI entrez gene - 114433     See in Manteia.
swissprot - Q90VV9
ZFIN ID - ZDB-GENE-010607-2
Ensembl - ENSDARG00000094132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGF-IENSGALG00000012755Gallus gallus
 IGF1ENSG00000017427Homo sapiens
 Igf1ENSMUSG00000020053Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
igf2b / insulin-like growth factor 2b / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*ENSDARG0000003330739
igf2a / insulin-like growth factor 2a / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*ENSDARG0000001864333
igf3 / insulin-like growth factor 3ENSDARG0000005805830


Protein motifs (from Interpro)
Interpro ID Name
 IPR016179  Insulin-like
 IPR022341  Insulin-like growth factor I
 IPR022350  Insulin-like growth factor
 IPR022352  Insulin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IPI
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / complex / reaction
 ENSDARG00000027423 igf1ra / insulin-like growth factor 1a receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*  / reaction / complex
 ENSDARG00000031422 igfbp2b / insulin-like growth factor binding protein 2b / P47877* / IGFBP2* / P18065* / insulin like growth factor binding protein 2*  / complex / reaction
 ENSDARG00000034434 igf1rb / insulin-like growth factor 1b receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*  / complex / reaction
 ENSDARG00000023111 plg / plasminogen / LPA* / P08519* / P20918* / P00747* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSDARG00000038666 igfbp1b / insulin-like growth factor binding protein 1b / P47876* / IGFBP1* / P08833* / insulin like growth factor binding protein 1*  / reaction / complex
 ENSDARG00000039264 igfbp5a / insulin-like growth factor binding protein 5a / IGFBP5* / P24593* / insulin like growth factor binding protein 5*  / reaction / complex
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / reaction / complex
 ENSDARG00000052470 Q9PTH3 / igfbp2a / insulin-like growth factor binding protein 2a / IGFBP2* / P18065* / insulin like growth factor binding protein 2*  / complex / reaction
 ENSDARG00000025348 igfbp5b / insulin-like growth factor binding protein 5b / Q07079* / IGFBP5* / P24593* / insulin like growth factor binding protein 5*  / reaction / complex
 ENSDARG00000037836 igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction / complex
 ENSDARG00000076020 pappa2 / pappalysin 2 / Q9BXP8*  / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000070941 igfbp6a / insulin-like growth factor binding protein 6a / IGFBP6* / P24592* / insulin like growth factor binding protein 6*  / reaction / complex
 ENSDARG00000090833 igfbp6b / insulin-like growth factor binding protein 6b / IGFBP6* / P24592* / insulin like growth factor binding protein 6*  / reaction / complex
 ENSDARG00000099144 igfbp3 / insulin-like growth factor binding protein 3 / P17936* / P47878*  / complex / reaction






 

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