ENSDARG00000052470


Danio rerio

Features
Gene ID: ENSDARG00000052470
  
Biological name :igfbp2a
  
Synonyms : igfbp2a / insulin-like growth factor binding protein 2a / Q9PTH3
  
Possible biological names infered from orthology : IGFBP2 / insulin like growth factor binding protein 2 / P18065 / P47877
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 20921542
Gene end: 20952187
  
Corresponding Affymetrix probe sets: Dr.8149.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000068816
NCBI entrez gene - 794176     See in Manteia.
RefSeq - NM_131458
RefSeq Peptide - NP_571533
swissprot - Q9PTH3
ZFIN ID - ZDB-GENE-000125-12
Ensembl - ENSDARG00000052470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGFBP2ENSGALG00000011469Gallus gallus
 IGFBP2ENSG00000115457Homo sapiens
 Igfbp2ENSMUSG00000039323Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
igfbp2b / insulin-like growth factor binding protein 2b / P47877* / IGFBP2* / P18065* / insulin like growth factor binding protein 2*ENSDARG0000003142258
igfbp1a / insulin-like growth factor binding protein 1a / P47876* / IGFBP1* / P08833* / insulin like growth factor binding protein 1*ENSDARG0000009935129
igfbp5a / insulin-like growth factor binding protein 5a / IGFBP5* / P24593* / insulin like growth factor binding protein 5*ENSDARG0000003926427
igfbp5b / insulin-like growth factor binding protein 5b / Q07079* / IGFBP5* / P24593* / insulin like growth factor binding protein 5*ENSDARG0000002534826
igfbp3 / insulin-like growth factor binding protein 3 / P17936* / P47878*ENSDARG0000009914425
igfbp1b / insulin-like growth factor binding protein 1b / P47876* / IGFBP1* / P08833* / insulin like growth factor binding protein 1*ENSDARG0000003866624
igfbp6b / insulin-like growth factor binding protein 6b / IGFBP6* / P24592* / insulin like growth factor binding protein 6*ENSDARG0000009083321
igfbp6a / insulin-like growth factor binding protein 6a / IGFBP6* / P24592* / insulin like growth factor binding protein 6*ENSDARG0000007094118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR012210  Insulin-like growth factor binding protein 2
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008156 negative regulation of DNA replication IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0040007 growth IMP
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway IMP
 biological_processGO:0048640 negative regulation of developmental growth IMP
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IDA
 molecular_functionGO:0031995 insulin-like growth factor II binding IPI


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000094132 igf1 / insulin-like growth factor 1 / P05017* / P05019* / Insulin-like growth factor I *  / reaction / complex
 ENSDARG00000033307 igf2b / insulin-like growth factor 2b / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / reaction / complex






 

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