ENSDARG00000099144


Danio rerio

Features
Gene ID: ENSDARG00000099144
  
Biological name :igfbp3
  
Synonyms : igfbp3 / insulin-like growth factor binding protein 3
  
Possible biological names infered from orthology : P17936 / P47878
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 6756247
Gene end: 6804237
  
Corresponding Affymetrix probe sets: Dr.12583.1.S1_at (Zebrafish Array)   Dr.12583.2.A1_at (Zebrafish Array)   NM_205751_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000136501
Ensembl peptide - ENSDARP00000135216
NCBI entrez gene - 403079     See in Manteia.
RefSeq - NM_205751
RefSeq Peptide - NP_991314
swissprot - A0A0R4IPP4
swissprot - Q66I28
ZFIN ID - ZDB-GENE-040412-1
Ensembl - ENSDARG00000099144
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGFBP3ENSGALG00000037940Gallus gallus
 IGFBP3ENSG00000146674Homo sapiens
 Igfbp3ENSMUSG00000020427Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
igfbp5a / insulin-like growth factor binding protein 5a / IGFBP5* / P24593* / insulin like growth factor binding protein 5*ENSDARG0000003926435
igfbp5b / insulin-like growth factor binding protein 5b / Q07079* / IGFBP5* / P24593* / insulin like growth factor binding protein 5*ENSDARG0000002534834
igfbp6b / insulin-like growth factor binding protein 6b / IGFBP6* / P24592* / insulin like growth factor binding protein 6*ENSDARG0000009083325
igfbp1a / insulin-like growth factor binding protein 1a / P47876* / IGFBP1* / P08833* / insulin like growth factor binding protein 1*ENSDARG0000009935124
Q9PTH3 / igfbp2a / insulin-like growth factor binding protein 2a / IGFBP2* / P18065* / insulin like growth factor binding protein 2*ENSDARG0000005247024
igfbp2b / insulin-like growth factor binding protein 2b / P47877* / IGFBP2* / P18065* / insulin like growth factor binding protein 2*ENSDARG0000003142223
igfbp1b / insulin-like growth factor binding protein 1b / P47876* / IGFBP1* / P08833* / insulin like growth factor binding protein 1*ENSDARG0000003866622
igfbp6a / insulin-like growth factor binding protein 6a / IGFBP6* / P24592* / insulin like growth factor binding protein 6*ENSDARG0000007094121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR012211  Insulin-like growth factor binding protein 3
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IGI
 biological_processGO:0030916 otic vesicle formation IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway IBA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEP
 biological_processGO:0060037 pharyngeal system development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005634 nucleus ISS
 molecular_functionGO:0001968 fibronectin binding IBA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IDA
 molecular_functionGO:0031995 insulin-like growth factor II binding IDA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000152 retina retina tissue regeneration process quality , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch non-functional , abnormal
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 ZFA:0005147 regenerating tissue regenerating tissue Muller cell decreased amount , abnormal
Show

 ZFA:0009280 Muller cell Muller cell cell proliferation decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000023111 plg / plasminogen / LPA* / P08519* / P20918* / P00747* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSDARG00000037836 igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / complex / reaction
 ENSDARG00000094132 igf1 / insulin-like growth factor 1 / P05017* / P05019* / Insulin-like growth factor I *  / complex / reaction
 ENSDARG00000033307 igf2b / insulin-like growth factor 2b / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / complex / reaction






 

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