ENSGALG00000037940


Gallus gallus

Features
Gene ID: ENSGALG00000037940
  
Biological name :IGFBP3
  
Synonyms : IGFBP3 / insulin like growth factor binding protein 3
  
Possible biological names infered from orthology : P17936 / P47878
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 55103568
Gene end: 55119141
  
Corresponding Affymetrix probe sets: Gga.11476.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000055577
NCBI entrez gene - 420790     See in Manteia.
RefSeq - NM_001101034
RefSeq Peptide - NP_001094504
swissprot - A6N8N6
Ensembl - ENSGALG00000037940
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp3ENSDARG00000099144Danio rerio
 IGFBP3ENSG00000146674Homo sapiens
 Igfbp3ENSMUSG00000020427Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGFBP5 / insulin like growth factor binding protein 5 / P24593* / Q07079*ENSGALG0000001146840
IGFBP1 / insulin-like growth factor-binding protein 1 precursor / P08833* / P47876* / insulin like growth factor binding protein 1*ENSGALG0000004349330
IGFBP2 / insulin-like growth factor-binding protein 2 precursor / P18065* / P47877* / insulin like growth factor binding protein 2*ENSGALG0000001146929
IGFBP4 / insulin-like growth factor-binding protein 4 precursor / P22692* / P47879* / insulin like growth factor binding protein 4*ENSGALG0000004067229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR012211  Insulin-like growth factor binding protein 3
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0044342 type B pancreatic cell proliferation IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0042567 insulin-like growth factor ternary complex IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008160 protein tyrosine phosphatase activator activity IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004293 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction
 ENSGALG00000003580 MMP2 / Q90611 / 72 kDa type IV collagenase / P08253* / P33434* / matrix metallopeptidase 2* / 72 kDa type IV collagenase PEX*  / reaction
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSGALG00000012755 IGF-I / P18254 / Insulin-like growth factor I / IGF1* / P05017* / P05019* / insulin like growth factor 1*  / complex / reaction
 ENSGALG00000019061 MMP1* / MMP8* / Mmp1b* / Mmp1a* / P22894* / P03956* / O70138* / Neutrophil collagenase * / matrix metallopeptidase 1* / matrix metallopeptidase 8* / interstitial collagenase A preproprotein *  / reaction
 ENSGALG00000035282 IGF2 / P33717 / Insulin-like growth factor II / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / reaction / complex
 ENSGALG00000028886 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction






 

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