ENSMUSG00000020427


Mus musculus

Features
Gene ID: ENSMUSG00000020427
  
Biological name :Igfbp3
  
Synonyms : Igfbp3 / Insulin-like growth factor-binding protein 3 / P47878
  
Possible biological names infered from orthology : P17936
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 7206086
Gene end: 7213923
  
Corresponding Affymetrix probe sets: 10384223 (MoGene1.0st)   1423062_at (Mouse Genome 430 2.0 Array)   1458268_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020702
Ensembl peptide - ENSMUSP00000131670
NCBI entrez gene - 16009     See in Manteia.
MGI - MGI:96438
RefSeq - XM_011243665
RefSeq - NM_008343
RefSeq Peptide - NP_032369
swissprot - P47878
Ensembl - ENSMUSG00000020427
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp3ENSDARG00000099144Danio rerio
 IGFBP3ENSGALG00000037940Gallus gallus
 IGFBP3ENSG00000146674Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igfbp5 / Q07079 / Insulin-like growth factor-binding protein 5 / P24593*ENSMUSG0000002618540
Igfbp2 / P47877 / Insulin-like growth factor-binding protein 2 / P18065*ENSMUSG0000003932330
Igfbp4 / P47879 / Insulin-like growth factor-binding protein 4 / P22692*ENSMUSG0000001749329
Igfbp6 / P47880 / Insulin-like growth factor-binding protein 6 / P24592*ENSMUSG0000002304627
Igfbp1 / P47876 / Insulin-like growth factor-binding protein 1 / P08833*ENSMUSG0000002042927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR012211  Insulin-like growth factor binding protein 3
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IGI
 biological_processGO:0001649 osteoblast differentiation IEP
 biological_processGO:0001933 negative regulation of protein phosphorylation ISO
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0010906 regulation of glucose metabolic process IGI
 biological_processGO:0014912 negative regulation of smooth muscle cell migration ISO
 biological_processGO:0040008 regulation of growth IGI
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043410 positive regulation of MAPK cascade IGI
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IGI
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0044342 type B pancreatic cell proliferation IGI
 biological_processGO:0045663 positive regulation of myoblast differentiation ISO
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0042567 insulin-like growth factor ternary complex ISO
 molecular_functionGO:0001968 fibronectin binding IDA
 molecular_functionGO:0005520 insulin-like growth factor binding IPI
 molecular_functionGO:0008160 protein tyrosine phosphatase activator activity ISO
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IBA
 molecular_functionGO:0031995 insulin-like growth factor II binding IBA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
TP53 Regulates Transcription of Death Receptors and Ligands
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Ift122sopb/Ift122sopb,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008961 abnormal basal metabolism "any anomaly in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009427 increased tibialis anterior weight "increase in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0010226 increased quadriceps weight "increase in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0010227 decreased quadriceps weight "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / complex / reaction
 ENSMUSG00000040314 Ctsg / P28293 / cathepsin G / P08311*  / reaction
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / reaction
 ENSMUSG00000060538 Q9D123 / Tmem219 / transmembrane protein 219 / Q86XT9*  / reaction / complex
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000031740 Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*  / reaction
 ENSMUSG00000046070 Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / complex / reaction
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / complex / reaction
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction






 

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