ENSMUSG00000040314


Mus musculus

Features
Gene ID: ENSMUSG00000040314
  
Biological name :Ctsg
  
Synonyms : cathepsin G / Ctsg / P28293
  
Possible biological names infered from orthology : P08311
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 56099881
Gene end: 56102574
  
Corresponding Affymetrix probe sets: 10420261 (MoGene1.0st)   1419594_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015583
NCBI entrez gene - 13035     See in Manteia.
MGI - MGI:88563
RefSeq - NM_007800
RefSeq Peptide - NP_031826
swissprot - P28293
swissprot - Q059V7
Ensembl - ENSMUSG00000040314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gzm3ENSDARG00000078451Danio rerio
 gzm3.2ENSDARG00000055986Danio rerio
 gzm3.3ENSDARG00000093990Danio rerio
 gzm3.4ENSDARG00000076814Danio rerio
 ENSGALG00000044661Gallus gallus
 CTSGENSG00000100448Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gzmb / P04187 / granzyme B / P10144*ENSMUSG0000001543753
Gzmc / P08882 / Granzyme C / GZMB* / P10144* / granzyme B*ENSMUSG0000007918649
Gzme / P08884 / Granzyme E / GZMH* / P20718* / granzyme H*ENSMUSG0000002215647
Mcpt4 / mast cell protease 4ENSMUSG0000006106846
Gzmg / P13366 / granzyme G / GZMH* / P20718* / granzyme H*ENSMUSG0000004028446
Mcpt8 / P43430 / Mast cell protease 8 ENSMUSG0000002215746
Gzmn / granzyme N / GZMH* / P20718* / granzyme H*ENSMUSG0000001544345
Gzmf / P08883 / Granzyme F / GZMH* / P20718* / granzyme H*ENSMUSG0000001544145
Gzmd / P11033 / Granzyme D / GZMH* / P20718* / granzyme H*ENSMUSG0000005925645
Mcpt1 / P11034 / Mast cell protease 1 ENSMUSG0000002222744
Cma2 / chymase 2, mast cellENSMUSG0000006828943
Mcpt9 / O35164 / Mast cell protease 9 ENSMUSG0000007136143
Cma1 / P21844 / Chymase / P23946* / chymase 1*ENSMUSG0000002222541
Mcpt2 / P15119 / mast cell protease 2ENSMUSG0000002222641
Gzmm / granzyme M isoform 2 / P51124* / granzyme M*ENSMUSG0000005420637
Prss57 / Q14B24 / Serine protease 57 / Q6UWY2*ENSMUSG0000002032334
Gzma / P11032 / Granzyme A / P12544*ENSMUSG0000002313233
Cfd / P03953 / Complement factor D / P00746*ENSMUSG0000006178031
Gzmk / O35205 / Granzyme K / P49863*ENSMUSG0000004238530


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0019731 antibacterial humoral response IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0050778 positive regulation of immune response IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:0070946 neutrophil mediated killing of gram-positive bacterium IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008236 serine-type peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Metabolism of Angiotensinogen to Angiotensins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Neutrophil degranulation
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Ctsgtm3.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsgtm2.1(PML/RARA)Ley
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ctsgtm1Ley/Ctsgtm2.1(PML/RARA)Ley
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

Allelic Composition: Ctsgtm2(PML/RARA)Ley/Ctsgtm2(PML/RARA)Ley
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0004049 acute promyelocytic leukemia "rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctsgtm3.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctsgtm3.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctsgtm3.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009787 increased susceptibility to infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020427 Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*  / reaction
 ENSMUSG00000031980 Agt / angiotensinogen / P01019*  / reaction
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / reaction
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / reaction
 ENSMUSG00000046070 Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr