ENSMUSG00000022225


Mus musculus

Features
Gene ID: ENSMUSG00000022225
  
Biological name :Cma1
  
Synonyms : Chymase / Cma1 / P21844
  
Possible biological names infered from orthology : chymase 1 / P23946
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 55941451
Gene end: 55944675
  
Corresponding Affymetrix probe sets: 10420225 (MoGene1.0st)   1449456_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154406
Ensembl peptide - ENSMUSP00000022834
NCBI entrez gene - 17228     See in Manteia.
MGI - MGI:96941
RefSeq - NM_010780
RefSeq Peptide - NP_034910
swissprot - A4QPC5
swissprot - P21844
Ensembl - ENSMUSG00000022225
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gzm3ENSDARG00000078451Danio rerio
 gzm3.2ENSDARG00000055986Danio rerio
 gzm3.3ENSDARG00000093990Danio rerio
 gzm3.4ENSDARG00000076814Danio rerio
 ENSGALG00000044661Gallus gallus
 CMA1ENSG00000092009Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcpt4 / mast cell protease 4ENSMUSG0000006106855
Mcpt1 / P11034 / Mast cell protease 1 ENSMUSG0000002222750
Cma2 / chymase 2, mast cellENSMUSG0000006828949
Mcpt9 / O35164 / Mast cell protease 9 ENSMUSG0000007136148
Mcpt2 / P15119 / mast cell protease 2ENSMUSG0000002222646
Gzmb / P04187 / granzyme B / P10144*ENSMUSG0000001543743
Ctsg / P28293 / cathepsin G / P08311*ENSMUSG0000004031442
Gzmf / P08883 / Granzyme F / GZMH* / P20718* / granzyme H*ENSMUSG0000001544142
Gzmg / P13366 / granzyme G / GZMH* / P20718* / granzyme H*ENSMUSG0000004028441
Mcpt8 / P43430 / Mast cell protease 8 ENSMUSG0000002215741
Gzmc / P08882 / Granzyme C / GZMB* / P10144* / granzyme B*ENSMUSG0000007918641
Gzmd / P11033 / Granzyme D / GZMH* / P20718* / granzyme H*ENSMUSG0000005925640
Gzme / P08884 / Granzyme E / GZMH* / P20718* / granzyme H*ENSMUSG0000002215640
Gzmn / granzyme N / GZMH* / P20718* / granzyme H*ENSMUSG0000001544340
Gzma / P11032 / Granzyme A / P12544*ENSMUSG0000002313234
Gzmm / granzyme M isoform 2 / P51124* / granzyme M*ENSMUSG0000005420632
Gzmk / O35205 / Granzyme K / P49863*ENSMUSG0000004238532
Prss57 / Q14B24 / Serine protease 57 / Q6UWY2*ENSMUSG0000002032330
Cfd / P03953 / Complement factor D / P00746*ENSMUSG0000006178029


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006518 peptide metabolic process IEA
 biological_processGO:0022617 extracellular matrix disassembly IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0034769 basement membrane disassembly IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0050720 interleukin-1 beta biosynthetic process IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0030141 secretory granule IBA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004175 endopeptidase activity ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Activation of Matrix Metalloproteinases
Metabolism of Angiotensinogen to Angiotensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nphp3pcy/Nphp3pcy
Genetic Background: involves: KK

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction
 ENSMUSG00000031980 Agt / angiotensinogen / P01019*  / reaction






 

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