ENSMUSG00000022157


Mus musculus

Features
Gene ID: ENSMUSG00000022157
  
Biological name :Mcpt8
  
Synonyms : Mast cell protease 8 / Mcpt8 / P43430
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 56082166
Gene end: 56085273
  
Corresponding Affymetrix probe sets: 10420254 (MoGene1.0st)   1449965_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015594
Ensembl peptide - ENSMUSP00000153507
NCBI entrez gene - 17231     See in Manteia.
MGI - MGI:1261780
RefSeq - XM_006518671
RefSeq - NM_008572
RefSeq Peptide - NP_032598
swissprot - P43430
swissprot - Q3UWB6
swissprot - A0A286YDN6
Ensembl - ENSMUSG00000022157
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gzm3ENSDARG00000078451Danio rerio
 gzm3.2ENSDARG00000055986Danio rerio
 gzm3.3ENSDARG00000093990Danio rerio
 gzm3.4ENSDARG00000076814Danio rerio
 ENSGALG00000044661Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gzmb / P04187 / granzyme B / P10144*ENSMUSG0000001543750
Ctsg / P28293 / cathepsin G / P08311*ENSMUSG0000004031448
Gzmc / P08882 / Granzyme C / GZMB* / P10144* / granzyme B*ENSMUSG0000007918648
Gzmg / P13366 / granzyme G / GZMH* / P20718* / granzyme H*ENSMUSG0000004028447
Mcpt2 / P15119 / mast cell protease 2ENSMUSG0000002222647
Mcpt9 / O35164 / Mast cell protease 9 ENSMUSG0000007136145
Gzmf / P08883 / Granzyme F / GZMH* / P20718* / granzyme H*ENSMUSG0000001544145
Cma2 / chymase 2, mast cellENSMUSG0000006828944
Gzme / P08884 / Granzyme E / GZMH* / P20718* / granzyme H*ENSMUSG0000002215644
Gzmn / granzyme N / GZMH* / P20718* / granzyme H*ENSMUSG0000001544344
Mcpt1 / P11034 / Mast cell protease 1 ENSMUSG0000002222744
Gzmd / P11033 / Granzyme D / GZMH* / P20718* / granzyme H*ENSMUSG0000005925643
Cma1 / P21844 / Chymase / P23946* / chymase 1*ENSMUSG0000002222543
Mcpt4 / mast cell protease 4ENSMUSG0000006106843
Gzmm / granzyme M isoform 2 / P51124* / granzyme M*ENSMUSG0000005420637
Gzma / P11032 / Granzyme A / P12544*ENSMUSG0000002313236
Gzmk / O35205 / Granzyme K / P49863*ENSMUSG0000004238533
Prss57 / Q14B24 / Serine protease 57 / Q6UWY2*ENSMUSG0000002032333
Cfd / P03953 / Complement factor D / P00746*ENSMUSG0000006178030


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0030141 secretory granule IBA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: Celsr1Crsh/Celsr1+,Ptk7chz/Ptk7+
Genetic Background: involves: 101/H * BALB/c * BALB/cAnN * C3H/HeH

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Celsr1Crsh/Celsr1+,Ptk7chz/Ptk7+
Genetic Background: involves: 101/H * BALB/c * BALB/cAnN * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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