ENSMUSG00000023132


Mus musculus

Features
Gene ID: ENSMUSG00000023132
  
Biological name :Gzma
  
Synonyms : Granzyme A / Gzma / P11032
  
Possible biological names infered from orthology : P12544
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D2.2
Gene start: 113093825
Gene end: 113100981
  
Corresponding Affymetrix probe sets: 10412211 (MoGene1.0st)   1417898_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023897
Ensembl peptide - ENSMUSP00000153593
NCBI entrez gene - 14938     See in Manteia.
MGI - MGI:109266
RefSeq - NM_010370
RefSeq Peptide - NP_034500
swissprot - P11032
swissprot - Q3U0N0
Ensembl - ENSMUSG00000023132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GZMAENSGALG00000013548Gallus gallus
 GZMAENSG00000145649Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gzmk / O35205 / Granzyme K / P49863*ENSMUSG0000004238542
Gzmb / P04187 / granzyme B / P10144*ENSMUSG0000001543739
Gzmc / P08882 / Granzyme C / GZMB* / P10144* / granzyme B*ENSMUSG0000007918637
Gzmd / P11033 / Granzyme D / GZMH* / P20718* / granzyme H*ENSMUSG0000005925636
Gzmf / P08883 / Granzyme F / GZMH* / P20718* / granzyme H*ENSMUSG0000001544136
Gzme / P08884 / Granzyme E / GZMH* / P20718* / granzyme H*ENSMUSG0000002215636
Mcpt2 / P15119 / mast cell protease 2ENSMUSG0000002222635
Cma2 / chymase 2, mast cellENSMUSG0000006828935
Mcpt1 / P11034 / Mast cell protease 1 ENSMUSG0000002222735
Mcpt9 / O35164 / Mast cell protease 9 ENSMUSG0000007136135
Gzmg / P13366 / granzyme G / GZMH* / P20718* / granzyme H*ENSMUSG0000004028435
Mcpt4 / mast cell protease 4ENSMUSG0000006106835
Cma1 / P21844 / Chymase / P23946* / chymase 1*ENSMUSG0000002222534
Gzmn / granzyme N / GZMH* / P20718* / granzyme H*ENSMUSG0000001544334
Mcpt8 / P43430 / Mast cell protease 8 ENSMUSG0000002215734
Ctsg / P28293 / cathepsin G / P08311*ENSMUSG0000004031433
Cfd / P03953 / Complement factor D / P00746*ENSMUSG0000006178033
Gzmm / granzyme M isoform 2 / P51124* / granzyme M*ENSMUSG0000005420632
Prss57 / Q14B24 / Serine protease 57 / Q6UWY2*ENSMUSG0000002032332


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0032078 negative regulation of endodeoxyribonuclease activity IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0051354 negative regulation of oxidoreductase activity IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prf1tm1Tsc/Prf1tm1Tsc
Genetic Background: 129X1.129S2-Prf1tm1Tsc

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz

Allelic Composition: Fastm1Osa/Fastm1Osa,Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz

Allelic Composition: Gzmatm1Ley/Gzmatm1Ley,Gzmbtm1Ley/Gzmbtm1Ley
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gzmatm1Ley/Gzmatm1Ley,Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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