ENSMUSG00000015437


Mus musculus

Features
Gene ID: ENSMUSG00000015437
  
Biological name :Gzmb
  
Synonyms : granzyme B / Gzmb / P04187
  
Possible biological names infered from orthology : P10144
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 56258838
Gene end: 56262260
  
Corresponding Affymetrix probe sets: 10420308 (MoGene1.0st)   1419060_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015581
NCBI entrez gene - 14939     See in Manteia.
MGI - MGI:109267
RefSeq - NM_013542
RefSeq Peptide - NP_038570
swissprot - P04187
swissprot - Q3TZH4
Ensembl - ENSMUSG00000015437
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gzm3ENSDARG00000078451Danio rerio
 gzm3.2ENSDARG00000055986Danio rerio
 gzm3.3ENSDARG00000093990Danio rerio
 gzm3.4ENSDARG00000076814Danio rerio
 ENSGALG00000044661Gallus gallus
 GZMBENSG00000100453Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gzmc / P08882 / Granzyme C / GZMB* / P10144* / granzyme B*ENSMUSG0000007918666
Gzmg / P13366 / granzyme G / GZMH* / P20718* / granzyme H*ENSMUSG0000004028458
Gzmd / P11033 / Granzyme D / GZMH* / P20718* / granzyme H*ENSMUSG0000005925657
Gzmf / P08883 / Granzyme F / GZMH* / P20718* / granzyme H*ENSMUSG0000001544157
Ctsg / P28293 / cathepsin G / P08311*ENSMUSG0000004031456
Gzme / P08884 / Granzyme E / GZMH* / P20718* / granzyme H*ENSMUSG0000002215655
Gzmn / granzyme N / GZMH* / P20718* / granzyme H*ENSMUSG0000001544353
Mcpt8 / P43430 / Mast cell protease 8 ENSMUSG0000002215750
Mcpt4 / mast cell protease 4ENSMUSG0000006106849
Mcpt9 / O35164 / Mast cell protease 9 ENSMUSG0000007136147
Mcpt1 / P11034 / Mast cell protease 1 ENSMUSG0000002222746
Mcpt2 / P15119 / mast cell protease 2ENSMUSG0000002222646
Cma2 / chymase 2, mast cellENSMUSG0000006828946
Cma1 / P21844 / Chymase / P23946* / chymase 1*ENSMUSG0000002222545
Gzma / P11032 / Granzyme A / P12544*ENSMUSG0000002313241
Prss57 / Q14B24 / Serine protease 57 / Q6UWY2*ENSMUSG0000002032340
Gzmk / O35205 / Granzyme K / P49863*ENSMUSG0000004238537
Gzmm / granzyme M isoform 2 / P51124* / granzyme M*ENSMUSG0000005420636
Cfd / P03953 / Complement factor D / P00746*ENSMUSG0000006178032


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR037553  Granzyme B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001913 T cell mediated cytotoxicity IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008626 granzyme-mediated apoptotic signaling pathway IMP
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030141 secretory granule IBA
 cellular_componentGO:0044194 cytolytic granule IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation, myristolyation of BID and translocation to mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz

 MP:0002436 abnormal cytotoxic T cell morphology/development "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gzmbtm1Ley/Gzmbtm1Ley,Serpinb9tm1Arp/Serpinb9tm1Arp
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Prf1tm1Tsc/Prf1tm1Tsc
Genetic Background: 129X1.129S2-Prf1tm1Tsc

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz

Allelic Composition: Fastm1Osa/Fastm1Osa,Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Mjk/Prrx2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gzmbtm1Ley/Gzmbtm1Ley,Serpinb9tm1Arp/Serpinb9tm1Arp
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gzmbtm2Ley/Gzmbtm2Ley
Genetic Background: 129X1/SvJ-Gzmbtm2Ley

Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm,Prrx2tm1Mjk/Prrx2tm1Mjk
Genetic Background: involves: 129S4/SvJaeSor

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prf1tm1Tsc/Prf1tm1Tsc
Genetic Background: 129X1.129S2-Prf1tm1Tsc

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz

Allelic Composition: Gzmbtm1Ley/Gzmbtm1Ley
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gzmatm1Ley/Gzmatm1Ley,Gzmbtm1Ley/Gzmbtm1Ley
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gzmatm1Ley/Gzmatm1Ley,Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: involves: 129X1/SvJ

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Gzmbtm1Ley/Gzmbtm1Ley
Genetic Background: involves: 129X1/SvJ

 MP:0012191 decreased cytotoxic T cell apoptosis "decrease in the number of cytotoxic T cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Dzip1lwarpy/Dzip1lwarpy
Genetic Background: involves: C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004446 Bid / P70444 / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11 / P55957* / BH...  / reaction






 

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