ENSG00000100453


Homo sapiens

Features
Gene ID: ENSG00000100453
  
Biological name :GZMB
  
Synonyms : granzyme B / GZMB / P10144
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q12
Gene start: 24630954
Gene end: 24634267
  
Corresponding Affymetrix probe sets: 210164_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432074
Ensembl peptide - ENSP00000434213
Ensembl peptide - ENSP00000479643
Ensembl peptide - ENSP00000450535
Ensembl peptide - ENSP00000435084
Ensembl peptide - ENSP00000216341
Ensembl peptide - ENSP00000371980
Ensembl peptide - ENSP00000371982
Ensembl peptide - ENSP00000387385
NCBI entrez gene - 3002     See in Manteia.
OMIM - 123910
RefSeq - XM_011536685
RefSeq - NM_001346011
RefSeq - NM_004131
RefSeq Peptide - NP_004122
RefSeq Peptide - NP_001332940
swissprot - Q6XGZ2
swissprot - E9PRD7
swissprot - P10144
swissprot - E9PLX4
swissprot - J3KPK2
swissprot - E9PID1
swissprot - J3KQ52
Ensembl - ENSG00000100453
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gzm3ENSDARG00000078451Danio rerio
 gzm3.2ENSDARG00000055986Danio rerio
 gzm3.3ENSDARG00000093990Danio rerio
 gzm3.4ENSDARG00000076814Danio rerio
 ENSGALG00000044661Gallus gallus
 GzmbENSMUSG00000015437Mus musculus
 GzmcENSMUSG00000079186Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GZMH / P20718 / granzyme HENSG0000010045071
CTSG / P08311 / cathepsin GENSG0000010044857
CMA1 / P23946 / chymase 1ENSG0000009200952
GZMA / P12544 / granzyme AENSG0000014564939
PRSS57 / Q6UWY2 / serine protease 57ENSG0000018519839
GZMK / P49863 / granzyme KENSG0000011308837
GZMM / P51124 / granzyme MENSG0000019754036
CFD / P00746 / complement factor DENSG0000019776636


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR037553  Granzyme B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0008626 granzyme-mediated apoptotic signaling pathway IEA
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IEA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 cellular_componentGO:0001772 immunological synapse TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
NOTCH2 intracellular domain regulates transcription
Activation, myristolyation of BID and translocation to mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000015475 BID / P55957 / BH3 interacting domain death agonist  / reaction






 

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