ENSG00000092009


Homo sapiens

Features
Gene ID: ENSG00000092009
  
Biological name :CMA1
  
Synonyms : chymase 1 / CMA1 / P23946
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q12
Gene start: 24505353
Gene end: 24508265
  
Corresponding Affymetrix probe sets: 214533_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000206446
Ensembl peptide - ENSP00000250378
NCBI entrez gene - 1215     See in Manteia.
OMIM - 118938
RefSeq - NM_001308083
RefSeq - NM_001836
RefSeq Peptide - NP_001295012
RefSeq Peptide - NP_001827
swissprot - P23946
Ensembl - ENSG00000092009
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gzm3ENSDARG00000078451Danio rerio
 gzm3.2ENSDARG00000055986Danio rerio
 gzm3.3ENSDARG00000093990Danio rerio
 gzm3.4ENSDARG00000076814Danio rerio
 ENSGALG00000044661Gallus gallus
 Cma1ENSMUSG00000022225Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GZMB / P10144 / granzyme BENSG0000010045352
CTSG / P08311 / cathepsin GENSG0000010044851
GZMH / P20718 / granzyme HENSG0000010045048
GZMA / P12544 / granzyme AENSG0000014564938
PRSS57 / Q6UWY2 / serine protease 57ENSG0000018519838
GZMK / P49863 / granzyme KENSG0000011308836
CFD / P00746 / complement factor DENSG0000019776636
GZMM / P51124 / granzyme MENSG0000019754032


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002003 angiotensin maturation TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006518 peptide metabolic process IEA
 biological_processGO:0022617 extracellular matrix disassembly IDA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0034769 basement membrane disassembly IDA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0050720 interleukin-1 beta biosynthetic process IDA
 biological_processGO:0050727 regulation of inflammatory response IC
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0030141 secretory granule IBA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0004175 endopeptidase activity EXP
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity EXP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Activation of Matrix Metalloproteinases
Metabolism of Angiotensinogen to Angiotensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135744 AGT / P01019 / angiotensinogen  / reaction
 ENSG00000049130 KITLG / P21583 / KIT ligand  / reaction






 

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