ENSG00000100448


Homo sapiens

Features
Gene ID: ENSG00000100448
  
Biological name :CTSG
  
Synonyms : cathepsin G / CTSG / P08311
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q12
Gene start: 24573522
Gene end: 24576260
  
Corresponding Affymetrix probe sets: 205653_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000216336
NCBI entrez gene - 1511     See in Manteia.
OMIM - 116830
RefSeq - NM_001911
RefSeq - XM_011536499
RefSeq Peptide - NP_001902
swissprot - P08311
Ensembl - ENSG00000100448
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gzm3ENSDARG00000078451Danio rerio
 gzm3.2ENSDARG00000055986Danio rerio
 gzm3.3ENSDARG00000093990Danio rerio
 gzm3.4ENSDARG00000076814Danio rerio
 ENSGALG00000044661Gallus gallus
 CtsgENSMUSG00000040314Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GZMH / P20718 / granzyme HENSG0000010045055
GZMB / P10144 / granzyme BENSG0000010045355
CMA1 / P23946 / chymase 1ENSG0000009200950
PRSS57 / Q6UWY2 / serine protease 57ENSG0000018519838
GZMM / P51124 / granzyme MENSG0000019754037
GZMA / P12544 / granzyme AENSG0000014564936
CFD / P00746 / complement factor DENSG0000019776636
GZMK / P49863 / granzyme KENSG0000011308835


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002003 angiotensin maturation TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0019731 antibacterial humoral response IDA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044130 negative regulation of growth of symbiont in host IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0050778 positive regulation of immune response IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0050832 defense response to fungus IEA
 biological_processGO:0070946 neutrophil mediated killing of gram-positive bacterium IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008236 serine-type peptidase activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Metabolism of Angiotensinogen to Angiotensins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Neutrophil degranulation
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / reaction
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / reaction
 ENSG00000135744 AGT / P01019 / angiotensinogen  / reaction
 ENSG00000099769 IGFALS / P35858 / insulin like growth factor binding protein acid labile subunit  / reaction
 ENSG00000146674 IGFBP3 / P17936 / insulin like growth factor binding protein 3  / reaction






 

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