ENSG00000197540


Homo sapiens

Features
Gene ID: ENSG00000197540
  
Biological name :GZMM
  
Synonyms : granzyme M / GZMM / P51124
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 544034
Gene end: 549924
  
Corresponding Affymetrix probe sets: 207460_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264553
Ensembl peptide - ENSP00000476255
NCBI entrez gene - 3004     See in Manteia.
OMIM - 600311
RefSeq - NM_005317
RefSeq - NM_001258351
RefSeq Peptide - NP_001245280
RefSeq Peptide - NP_005308
swissprot - P51124
swissprot - U3KQV5
Ensembl - ENSG00000197540
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000015192Gallus gallus
 GzmmENSMUSG00000054206Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRSS57 / Q6UWY2 / serine protease 57ENSG0000018519840
CFD / P00746 / complement factor DENSG0000019776639
CTSG / P08311 / cathepsin GENSG0000010044837
GZMH / P20718 / granzyme HENSG0000010045036
GZMK / P49863 / granzyme KENSG0000011308835
GZMB / P10144 / granzyme BENSG0000010045335
GZMA / P12544 / granzyme AENSG0000014564932
CMA1 / P23946 / chymase 1ENSG0000009200931


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033040  Granzyme M
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008219 cell death IMP
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Alternative complement activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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