Manteia

ENSMUSG00000054206

Mus musculus

Features

Gene ID:	ENSMUSG00000054206

Biological name :	Gzmm

Synonyms :	granzyme M isoform 2 / Gzmm

Possible biological names infered from orthology :	granzyme M / P51124

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	C1
Gene start:	79689020
Gene end:	79695261

Corresponding Affymetrix probe sets:	10364460 (MoGene1.0st) 1449501_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000020549 NCBI entrez gene - 16904 See in Manteia. MGI - MGI:99549 RefSeq - XM_017313816 RefSeq - NM_001302485 RefSeq - NM_008504 RefSeq Peptide - NP_032530 RefSeq Peptide - NP_001289414 swissprot - O08643 Ensembl - ENSMUSG00000054206

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gzmc / P08882 / Granzyme C / GZMB* / P10144* / granzyme B*	ENSMUSG00000079186	36
Ctsg / P28293 / cathepsin G / P08311*	ENSMUSG00000040314	36
Prss57 / Q14B24 / Serine protease 57 / Q6UWY2*	ENSMUSG00000020323	36
Mcpt8 / P43430 / Mast cell protease 8	ENSMUSG00000022157	34
Gzmf / P08883 / Granzyme F / GZMH* / P20718* / granzyme H*	ENSMUSG00000015441	34
Gzmb / P04187 / granzyme B / P10144*	ENSMUSG00000015437	34
Mcpt1 / P11034 / Mast cell protease 1	ENSMUSG00000022227	34
Mcpt4 / mast cell protease 4	ENSMUSG00000061068	34
Gzmg / P13366 / granzyme G / GZMH* / P20718* / granzyme H*	ENSMUSG00000040284	34
Mcpt2 / P15119 / mast cell protease 2	ENSMUSG00000022226	33
Cma2 / chymase 2, mast cell	ENSMUSG00000068289	33
Gzmn / granzyme N / GZMH* / P20718* / granzyme H*	ENSMUSG00000015443	33
Mcpt9 / O35164 / Mast cell protease 9	ENSMUSG00000071361	32
Gzme / P08884 / Granzyme E / GZMH* / P20718* / granzyme H*	ENSMUSG00000022156	32
Cma1 / P21844 / Chymase / P23946* / chymase 1*	ENSMUSG00000022225	32
Cfd / P03953 / Complement factor D / P00746*	ENSMUSG00000061780	31
Gzma / P11032 / Granzyme A / P12544*	ENSMUSG00000023132	31
Gzmk / O35205 / Granzyme K / P49863*	ENSMUSG00000042385	31
Gzmd / P11033 / Granzyme D / GZMH* / P20718* / granzyme H*	ENSMUSG00000059256	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR001254	Serine proteases, trypsin domain
IPR001314	Peptidase S1A, chymotrypsin family
IPR009003	Peptidase S1, PA clan
IPR018114	Serine proteases, trypsin family, histidine active site
IPR033040	Granzyme M
IPR033116	Serine proteases, trypsin family, serine active site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0008219	cell death	ISO
biological_process	GO:0019835	cytolysis	IDA
molecular_function	GO:0004175	endopeptidase activity	IDA
molecular_function	GO:0004252	serine-type endopeptidase activity	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008236	serine-type peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA

Pathways (from Reactome)

Pathway description

Alternative complement activation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Mjk/Prrx2⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr