ENSG00000145649


Homo sapiens

Features
Gene ID: ENSG00000145649
  
Biological name :GZMA
  
Synonyms : granzyme A / GZMA / P12544
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q11.2
Gene start: 55102648
Gene end: 55110252
  
Corresponding Affymetrix probe sets: 205488_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000274306
NCBI entrez gene - 3001     See in Manteia.
OMIM - 140050
RefSeq - NM_006144
RefSeq Peptide - NP_006135
swissprot - P12544
Ensembl - ENSG00000145649
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GZMAENSGALG00000013548Gallus gallus
 GzmaENSMUSG00000023132Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GZMK / P49863 / granzyme KENSG0000011308839
CFD / P00746 / complement factor DENSG0000019776638
GZMB / P10144 / granzyme BENSG0000010045337
GZMH / P20718 / granzyme HENSG0000010045037
CMA1 / P23946 / chymase 1ENSG0000009200936
CTSG / P08311 / cathepsin GENSG0000010044835
PRSS57 / Q6UWY2 / serine protease 57ENSG0000018519831
GZMM / P51124 / granzyme MENSG0000019754031


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0032078 negative regulation of endodeoxyribonuclease activity IDA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0051354 negative regulation of oxidoreductase activity IDA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IDA
 cellular_componentGO:0001772 immunological synapse TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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