ENSG00000146674


Homo sapiens

Features
Gene ID: ENSG00000146674
  
Biological name :IGFBP3
  
Synonyms : IGFBP3 / insulin like growth factor binding protein 3 / P17936
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p12.3
Gene start: 45912245
Gene end: 45921874
  
Corresponding Affymetrix probe sets: 210095_s_at (Human Genome U133 Plus 2.0 Array)   212143_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370476
Ensembl peptide - ENSP00000389668
Ensembl peptide - ENSP00000480717
Ensembl peptide - ENSP00000477772
Ensembl peptide - ENSP00000399116
Ensembl peptide - ENSP00000390298
Ensembl peptide - ENSP00000275521
Ensembl peptide - ENSP00000370473
NCBI entrez gene - 3486     See in Manteia.
OMIM - 146732
RefSeq - XM_017012152
RefSeq - NM_000598
RefSeq - NM_001013398
RefSeq Peptide - NP_000589
RefSeq Peptide - NP_001013416
swissprot - H0Y5K2
swissprot - P17936
swissprot - C9JMX4
swissprot - B3KWK7
swissprot - A6XND0
swissprot - A6XND1
swissprot - H0Y485
Ensembl - ENSG00000146674
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp3ENSDARG00000099144Danio rerio
 IGFBP3ENSGALG00000037940Gallus gallus
 Igfbp3ENSMUSG00000020427Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGFBP5 / P24593 / insulin like growth factor binding protein 5ENSG0000011546141
IGFBP2 / P18065 / insulin like growth factor binding protein 2ENSG0000011545730
IGFBP6 / P24592 / insulin like growth factor binding protein 6ENSG0000016777929
IGFBP4 / P22692 / insulin like growth factor binding protein 4ENSG0000014175328
IGFBP1 / P08833 / insulin like growth factor binding protein 1ENSG0000014667826


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR012211  Insulin-like growth factor binding protein 3
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0009968 negative regulation of signal transduction NAS
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IDA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway IBA
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0044342 type B pancreatic cell proliferation IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IDA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0016942 insulin-like growth factor binding protein complex IC
 cellular_componentGO:0042567 insulin-like growth factor ternary complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008160 protein tyrosine phosphatase activator activity IDA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IPI
 molecular_functionGO:0031995 insulin-like growth factor II binding IBA
 molecular_functionGO:0046872 metal ion binding NAS


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
TP53 Regulates Transcription of Death Receptors and Ligands
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100448 CTSG / P08311 / cathepsin G  / reaction
 ENSG00000087245 MMP2 / P08253 / matrix metallopeptidase 2  / reaction
 ENSG00000149932 Q86XT9 / TMEM219 / transmembrane protein 219  / complex / reaction
 ENSG00000122194 PLG / P00747 / plasminogen  / reaction
 ENSG00000099769 IGFALS / P35858 / insulin like growth factor binding protein acid labile subunit  / complex / reaction
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / reaction / complex
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / complex / reaction
 ENSG00000180210 F2 / P00734 / coagulation factor II, thrombin  / reaction
 ENSG00000142515 KLK3 / P07288 / kallikrein related peptidase 3  / reaction
 ENSG00000196611 MMP1 / P03956 / matrix metallopeptidase 1  / reaction






 

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