ENSG00000146678


Homo sapiens

Features
Gene ID: ENSG00000146678
  
Biological name :IGFBP1
  
Synonyms : IGFBP1 / insulin like growth factor binding protein 1 / P08833
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p12.3
Gene start: 45888357
Gene end: 45893668
  
Corresponding Affymetrix probe sets: 205302_at (Human Genome U133 Plus 2.0 Array)   237989_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000275525
Ensembl peptide - ENSP00000417069
Ensembl peptide - ENSP00000413511
NCBI entrez gene - 3484     See in Manteia.
OMIM - 146730
RefSeq - NM_000596
RefSeq Peptide - NP_000587
swissprot - C9JXF9
swissprot - C9J6H2
swissprot - P08833
Ensembl - ENSG00000146678
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp1aENSDARG00000099351Danio rerio
 igfbp1bENSDARG00000038666Danio rerio
 IGFBP1ENSGALG00000043493Gallus gallus
 Igfbp1ENSMUSG00000020429Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGFBP2 / P18065 / insulin like growth factor binding protein 2ENSG0000011545733
IGFBP4 / P22692 / insulin like growth factor binding protein 4ENSG0000014175331
IGFBP3 / P17936 / insulin like growth factor binding protein 3ENSG0000014667430
IGFBP5 / P24593 / insulin like growth factor binding protein 5ENSG0000011546128
IGFBP6 / P24592 / insulin like growth factor binding protein 6ENSG0000016777925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata
 IPR022322  Insulin-like growth factor-binding protein 1
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0036499 PERK-mediated unfolded protein response TAS
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway IBA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IDA
 molecular_functionGO:0031995 insulin-like growth factor II binding IDA


Pathways (from Reactome)
Pathway description
ATF4 activates genes
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / complex / reaction
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / complex / reaction






 

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