ENSMUSG00000020429


Mus musculus

Features
Gene ID: ENSMUSG00000020429
  
Biological name :Igfbp1
  
Synonyms : Igfbp1 / Insulin-like growth factor-binding protein 1 / P47876
  
Possible biological names infered from orthology : P08833
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 7197782
Gene end: 7202546
  
Corresponding Affymetrix probe sets: 10374223 (MoGene1.0st)   1418918_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020704
NCBI entrez gene - 16006     See in Manteia.
MGI - MGI:96436
RefSeq - NM_008341
RefSeq Peptide - NP_032367
swissprot - P47876
Ensembl - ENSMUSG00000020429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp1aENSDARG00000099351Danio rerio
 igfbp1bENSDARG00000038666Danio rerio
 IGFBP1ENSGALG00000043493Gallus gallus
 IGFBP1ENSG00000146678Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igfbp2 / P47877 / Insulin-like growth factor-binding protein 2 / P18065*ENSMUSG0000003932334
Igfbp4 / P47879 / Insulin-like growth factor-binding protein 4 / P22692*ENSMUSG0000001749331
Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*ENSMUSG0000002042729
Igfbp5 / Q07079 / Insulin-like growth factor-binding protein 5 / P24593*ENSMUSG0000002618529
Igfbp6 / P47880 / Insulin-like growth factor-binding protein 6 / P24592*ENSMUSG0000002304622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata
 IPR022322  Insulin-like growth factor-binding protein 1
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IPI
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA
 molecular_functionGO:0031995 insulin-like growth factor II binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Men1tm1.2Ctre/Men1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Men1tm1.2Ctre/Men1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Men1tm1.2Ctre/Men1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Men1tm1.2Ctre/Men1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Men1tm1.2Ctre/Men1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Men1tm1.2Ctre/Men1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / reaction / complex
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / reaction / complex






 

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