ENSMUSG00000020053


Mus musculus

Features
Gene ID: ENSMUSG00000020053
  
Biological name :Igf1
  
Synonyms : Igf1 / Insulin-like growth factor I / P05017
  
Possible biological names infered from orthology : insulin like growth factor 1 / P05019
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 87858265
Gene end: 87937042
  
Corresponding Affymetrix probe sets: 10365559 (MoGene1.0st)   1419519_at (Mouse Genome 430 2.0 Array)   1434413_at (Mouse Genome 430 2.0 Array)   1437401_at (Mouse Genome 430 2.0 Array)   1452014_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113905
Ensembl peptide - ENSMUSP00000113177
Ensembl peptide - ENSMUSP00000114120
Ensembl peptide - ENSMUSP00000122188
Ensembl peptide - ENSMUSP00000056668
Ensembl peptide - ENSMUSP00000093005
Ensembl peptide - ENSMUSP00000100937
Ensembl peptide - ENSMUSP00000112878
NCBI entrez gene - 16000     See in Manteia.
MGI - MGI:96432
RefSeq - XM_017313812
RefSeq - NM_001111275
RefSeq - NM_001111276
RefSeq - NM_001314010
RefSeq - NM_010512
RefSeq - XM_006513255
RefSeq - XM_006513257
RefSeq - XM_006513258
RefSeq - XM_006513261
RefSeq - XM_006513262
RefSeq - XM_006513264
RefSeq - XM_017313810
RefSeq - XM_017313811
RefSeq - NM_001111274
RefSeq Peptide - NP_001104744
RefSeq Peptide - NP_001104745
RefSeq Peptide - NP_001104746
RefSeq Peptide - NP_001300939
RefSeq Peptide - NP_034642
swissprot - Q8CAR0
swissprot - E9Q138
swissprot - D3Z7M4
swissprot - E9PU89
swissprot - P05017
swissprot - Q4VJB9
swissprot - Q4VJC0
Ensembl - ENSMUSG00000020053
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igf1ENSDARG00000094132Danio rerio
 IGF-IENSGALG00000012755Gallus gallus
 IGF1ENSG00000017427Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*ENSMUSG0000004858333


Protein motifs (from Interpro)
Interpro ID Name
 IPR016179  Insulin-like
 IPR022341  Insulin-like growth factor I
 IPR022350  Insulin-like growth factor
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site
 IPR036438  Insulin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001649 osteoblast differentiation IEP
 biological_processGO:0001775 cell activation IEA
 biological_processGO:0001932 regulation of protein phosphorylation IDA
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007608 sensory perception of smell TAS
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0010001 glial cell differentiation IMP
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010560 positive regulation of glycoprotein biosynthetic process IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
 biological_processGO:0014896 muscle hypertrophy IEA
 biological_processGO:0014904 myotube cell development IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0021940 positive regulation of cerebellar granule cell precursor proliferation IDA
 biological_processGO:0030104 water homeostasis IGI
 biological_processGO:0030166 proteoglycan biosynthetic process IEA
 biological_processGO:0030324 lung development IGI
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032878 regulation of establishment or maintenance of cell polarity IDA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0035264 multicellular organism growth IDA
 biological_processGO:0035630 bone mineralization involved in bone maturation IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0045428 regulation of nitric oxide biosynthetic process IMP
 biological_processGO:0045445 myoblast differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045821 positive regulation of glycolytic process IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048468 cell development IMP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0048839 inner ear development IDA
 biological_processGO:0050650 chondroitin sulfate proteoglycan biosynthetic process IDA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051246 regulation of protein metabolic process IGI
 biological_processGO:0051450 myoblast proliferation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060283 negative regulation of oocyte development IEA
 biological_processGO:0060426 lung vasculature development IMP
 biological_processGO:0060463 lung lobe morphogenesis IMP
 biological_processGO:0060509 type I pneumocyte differentiation IMP
 biological_processGO:0060510 type II pneumocyte differentiation IMP
 biological_processGO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
 biological_processGO:0060736 prostate gland growth IMP
 biological_processGO:0060740 prostate gland epithelium morphogenesis IMP
 biological_processGO:0060741 prostate gland stromal morphogenesis IMP
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IMP
 biological_processGO:0061051 positive regulation of cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IGI
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IEA
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IDA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 biological_processGO:1904075 positive regulation of trophectodermal cell proliferation IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1905460 negative regulation of vascular associated smooth muscle cell apoptotic process IEA
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IMP
 biological_processGO:2000288 positive regulation of myoblast proliferation IMP
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex IEA
 cellular_componentGO:0042567 insulin-like growth factor ternary complex IEA
 cellular_componentGO:0070382 exocytic vesicle IDA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000039 abnormal otic capsule morphology "malformation of the cartilage or bony capsule surrounding the inner ear mechanism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Lif+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: C57BL/6J-Irf4m1Btlr

Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: C57BL/6J-Irf4m1Btlr

Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: C57BL/6J-Irf4m1Btlr

Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Tgfb1tm1N/Tgfb1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * NIH/Ola

Allelic Composition: Igf1tm2.1Nros/Igf1tm2.1Nros
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0001238 thin epidermal spinous layer "reduced thickness of the stratum spinosum; the polyhedral cell layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:15108]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

Allelic Composition: Igf1tm1.1Dlr/Igf1tm1.1Dlr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm2Arge/Igf1tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Igf1tm2Arge/Igf1tm2Arge,Tg(SERPINA1-cre)1Arge/0
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Igf1tm2.1Arge/Igf1tm2.1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Igf1tm2Arge/Igf1tm2.1Arge,Tg(SERPINA1-cre)1Arge/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Igf1tm2Arge/Igf1tm2.1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm2Arge/Igf1tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * DBA * MF1

Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Igf1tm2Arge/Igf1tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Igf1tm2.1Nros/Igf1tm2.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il13tm1Anjm/Il13+,Il4tm1.1Wep/Il4+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1.1Dlr/Igf1tm1.1Dlr
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Serpina1e-cre/ERT)1Sykr/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Lif+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il13tm1Anjm/Il13+,Il4tm1.1Wep/Il4+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb1tm1N/Tgfb1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * NIH/Ola

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * DBA * MF1

Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * DBA * MF1

Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0003429 insensitivity to growth hormone "no growth response to exogenous growth hormone" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Igf1tm1.1Dlr/Igf1tm1.1Dlr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: ArTfm EdaTa-25H/Y
Genetic Background: involves: 101/H * C3H/HeH

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Igf1tm2Arge/Igf1tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * DBA * MF1

Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0003956 abnormal body size "anomaly in the average body weight, height and/or length of an organism compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1.1Dlr/Igf1tm1.1Dlr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003986 small cochlear ganglion "reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm1Arge/Igf1+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004664 delayed inner ear development "slowed progression to structurally mature components of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Igf1tm2Arge/Igf1tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Igf1tm2Arge/Igf1tm2Arge,Tg(SERPINA1-cre)1Arge/0
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Igf1tm2.1Arge/Igf1tm2.1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Igf1tm2Arge/Igf1tm2.1Arge,Tg(SERPINA1-cre)1Arge/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Igf1tm2Arge/Igf1tm2.1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Serpina1e-cre/ERT)1Sykr/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004702 increased circulating insulin-like growth factor I level "increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0004716 abnormal cochlear nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004750 syndromic hearing loss "a form of progressive hearing loss that is usually associated with malformations of the external ear and other inherited signs and symptoms " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Igf1tm1.1Dlr/Igf1tm1.1Dlr
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * DBA * MF1

 MP:0005137 increased growth hormone level "greater than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Lif+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0005158 ovary hypoplasia "underdeveloped ovaries, usually due to reduced cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78931]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Igf1tm1.1Dlr/Igf1tm1.1Dlr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005600 increased ventricle muscle contractility "greater thant the normal ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: ArTfm EdaTa-25H/Y
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Serpina1e-cre/ERT)1Sykr/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Igf1tm2Arge/Igf1tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Igf1tm1.1Dlr/Igf1tm1.1Dlr
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm2Arge/Igf1tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Igf1tm2Arge/Igf1tm2Arge,Tg(SERPINA1-cre)1Arge/0
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008831 abnormal insulin-like growth factor I level "aomaly in the concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MESH:D12.644.276.937.400, MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * DBA * MF1

Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0009014 prolonged proestrus "increase in the length of the proestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0009018 short estrus "decrease in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0009090 myometrium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0009091 endometrium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0009096 decreased endometrial gland number "fewer than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
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Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0009364 abnormal mature ovarian follicle morphology "any structural abnormality in the ovarian follicle that is ready for ovulation and presents a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Igf1tm1.1Dlr/Igf1tm1.1Dlr
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Igf1tm2.1Nros/Igf1tm2.1Nros
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Igf1tm2.1Nros/Igf1+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0009946 abnormal olfactory bulb layer morphology "any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0009947 abnormal olfactory bulb external plexiform layer morphology "any structural anomaly of the part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer, which is mostly neuropil composed almost entirely of mitral and tufted cell dendrites, granule cell dendrites and their synaptic inputs" [NLX:nlx_96 "NeuroLex.org"]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0009951 abnormal olfactory bulb mitral cell layer morphology 
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0009954 abnormal mitral cell morphology "any structural anomaly of the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0010817 absent type I pneumocytes "absence of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Igf1tm2.1Nros/Igf1tm2.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gpc3tm1Arge/Gpc3tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf1tm1.1Dlr/Igf1tm1.1Dlr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Igf1tm2.1Nros/Igf1tm2.1Nros
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Igf1tm2Arge/Igf1tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Igf1tm2Arge/Igf1tm2Arge,Tg(SERPINA1-cre)1Arge/0
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Gpc3tm1Arge/Gpc3tm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Igf1tm1.1Dlr/Igf1tm1.1Dlr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0013400 abnormal endometrial gland development "aberrant formation or incomplete differentiation of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna, PMID:23619340]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005533 Igf1r / insulin like growth factor 1 receptor / P08069*  / reaction / complex
 ENSMUSG00000040314 Ctsg / P28293 / cathepsin G / P08311*  / reaction
 ENSMUSG00000020429 Igfbp1 / P47876 / Insulin-like growth factor-binding protein 1 / P08833*  / reaction / complex
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / reaction
 ENSMUSG00000017493 Igfbp4 / P47879 / Insulin-like growth factor-binding protein 4 / P22692*  / complex / reaction
 ENSMUSG00000023046 Igfbp6 / P47880 / Insulin-like growth factor-binding protein 6 / P24592*  / complex / reaction
 ENSMUSG00000026185 Igfbp5 / Q07079 / Insulin-like growth factor-binding protein 5 / P24593*  / complex / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000031740 Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*  / reaction
 ENSMUSG00000046070 Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / reaction / complex
 ENSMUSG00000039323 Igfbp2 / P47877 / Insulin-like growth factor-binding protein 2 / P18065*  / reaction / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex / reaction
 ENSMUSG00000054667 Irs4 / Q9Z0Y7 / Insulin receptor substrate 4 / O14654*  / complex / reaction
 ENSMUSG00000020427 Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction
 ENSMUSG00000028370 Pappa / Q8R4K8 / Pappalysin-1 / Q13219*  / reaction
 ENSMUSG00000073530 Pappa2 / pappalysin 2 / Q9BXP8*  / reaction






 

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