ENSMUSG00000026185


Mus musculus

Features
Gene ID: ENSMUSG00000026185
  
Biological name :Igfbp5
  
Synonyms : Igfbp5 / Insulin-like growth factor-binding protein 5 / Q07079
  
Possible biological names infered from orthology : P24593
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C3
Gene start: 72857932
Gene end: 72874884
  
Corresponding Affymetrix probe sets: 10355500 (MoGene1.0st)   1422313_a_at (Mouse Genome 430 2.0 Array)   1452114_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027377
NCBI entrez gene - 16011     See in Manteia.
MGI - MGI:96440
RefSeq - NM_010518
RefSeq Peptide - NP_034648
swissprot - Q07079
swissprot - Q3UQV0
Ensembl - ENSMUSG00000026185
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp5aENSDARG00000039264Danio rerio
 igfbp5bENSDARG00000025348Danio rerio
 IGFBP5ENSGALG00000011468Gallus gallus
 IGFBP5ENSG00000115461Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*ENSMUSG0000002042743
Igfbp4 / P47879 / Insulin-like growth factor-binding protein 4 / P22692*ENSMUSG0000001749334
Igfbp6 / P47880 / Insulin-like growth factor-binding protein 6 / P24592*ENSMUSG0000002304631
Igfbp2 / P47877 / Insulin-like growth factor-binding protein 2 / P18065*ENSMUSG0000003932330
Igfbp1 / P47876 / Insulin-like growth factor-binding protein 1 / P08833*ENSMUSG0000002042929


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR012213  Insulin-like growth factor binding protein 5
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IGI
 biological_processGO:0001649 osteoblast differentiation IEP
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0007565 female pregnancy IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0010906 regulation of glucose metabolic process IGI
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IGI
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway TAS
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IGI
 biological_processGO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0044342 type B pancreatic cell proliferation IGI
 biological_processGO:0045668 negative regulation of osteoblast differentiation IGI
 biological_processGO:0045926 negative regulation of growth IMP
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051146 striated muscle cell differentiation IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0060056 mammary gland involution IMP
 biological_processGO:0060416 response to growth hormone ISS
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:1901862 negative regulation of muscle tissue development IMP
 biological_processGO:1904205 negative regulation of skeletal muscle hypertrophy IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016942 insulin-like growth factor binding protein complex IC
 cellular_componentGO:0042567 insulin-like growth factor ternary complex IEA
 molecular_functionGO:0001968 fibronectin binding IDA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA
 molecular_functionGO:0031995 insulin-like growth factor II binding IBA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0010227 decreased quadriceps weight "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / reaction / complex
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / reaction / complex
 ENSMUSG00000046070 Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / complex / reaction
 ENSMUSG00000028370 Pappa / Q8R4K8 / Pappalysin-1 / Q13219*  / reaction
 ENSMUSG00000073530 Pappa2 / pappalysin 2 / Q9BXP8*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr