ENSMUSG00000028370


Mus musculus

Features
Gene ID: ENSMUSG00000028370
  
Biological name :Pappa
  
Synonyms : Pappa / Pappalysin-1 / Q8R4K8
  
Possible biological names infered from orthology : Q13219
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C1
Gene start: 65124174
Gene end: 65357509
  
Corresponding Affymetrix probe sets: 10505489 (MoGene1.0st)   1427633_a_at (Mouse Genome 430 2.0 Array)   1432591_at (Mouse Genome 430 2.0 Array)   1432592_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081545
NCBI entrez gene - 18491     See in Manteia.
MGI - MGI:97479
RefSeq - NM_021362
RefSeq - XM_006537672
RefSeq Peptide - NP_067337
swissprot - Q8R4K8
Ensembl - ENSMUSG00000028370
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pappaaENSDARG00000101090Danio rerio
 pappabENSDARG00000059858Danio rerio
 PAPPAENSGALG00000007079Gallus gallus
 PAPPAENSG00000182752Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pappa2 / pappalysin 2 / Q9BXP8*ENSMUSG0000007353045


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000800  Notch domain
 IPR006558  LamG-like jellyroll fold
 IPR008754  Peptidase M43, pregnancy-associated plasma-A
 IPR011936  Myxococcus cysteine-rich repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR030433  Pappalysin-1
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0032354 response to follicle-stimulating hormone IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004222 metalloendopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026185 Igfbp5 / Q07079 / Insulin-like growth factor-binding protein 5 / P24593*  / reaction
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / reaction
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / reaction
 ENSMUSG00000017493 Igfbp4 / P47879 / Insulin-like growth factor-binding protein 4 / P22692*  / reaction
 ENSMUSG00000046070 Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction






 

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