ENSMUSG00000017493


Mus musculus

Features
Gene ID: ENSMUSG00000017493
  
Biological name :Igfbp4
  
Synonyms : Igfbp4 / Insulin-like growth factor-binding protein 4 / P47879
  
Possible biological names infered from orthology : P22692
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 99041244
Gene end: 99054392
  
Corresponding Affymetrix probe sets: 10381096 (MoGene1.0st)   1421991_a_at (Mouse Genome 430 2.0 Array)   1421992_a_at (Mouse Genome 430 2.0 Array)   1423756_s_at (Mouse Genome 430 2.0 Array)   1423757_x_at (Mouse Genome 430 2.0 Array)   1437405_a_at (Mouse Genome 430 2.0 Array)   1437406_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135727
Ensembl peptide - ENSMUSP00000017637
Ensembl peptide - ENSMUSP00000135112
NCBI entrez gene - 16010     See in Manteia.
MGI - MGI:96439
RefSeq - NM_010517
RefSeq Peptide - NP_034647
swissprot - P47879
swissprot - H3BJT2
swissprot - H3BLB7
Ensembl - ENSMUSG00000017493
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGFBP4ENSGALG00000040672Gallus gallus
 IGFBP4ENSG00000141753Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igfbp5 / Q07079 / Insulin-like growth factor-binding protein 5 / P24593*ENSMUSG0000002618537
Igfbp2 / P47877 / Insulin-like growth factor-binding protein 2 / P18065*ENSMUSG0000003932335
Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*ENSMUSG0000002042733
Igfbp1 / P47876 / Insulin-like growth factor-binding protein 1 / P08833*ENSMUSG0000002042933
Igfbp6 / P47880 / Insulin-like growth factor-binding protein 6 / P24592*ENSMUSG0000002304628


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata
 IPR022327  Insulin-like growth factor-binding protein 4
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IGI
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0010906 regulation of glucose metabolic process IGI
 biological_processGO:0040008 regulation of growth IGI
 biological_processGO:0043410 positive regulation of MAPK cascade IGI
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IGI
 biological_processGO:0044342 type B pancreatic cell proliferation IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IBA
 molecular_functionGO:0031995 insulin-like growth factor II binding IBA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0010227 decreased quadriceps weight "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / reaction / complex
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / complex / reaction
 ENSMUSG00000028370 Pappa / Q8R4K8 / Pappalysin-1 / Q13219*  / reaction
 ENSMUSG00000073530 Pappa2 / pappalysin 2 / Q9BXP8*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr