ENSG00000141753


Homo sapiens

Features
Gene ID: ENSG00000141753
  
Biological name :IGFBP4
  
Synonyms : IGFBP4 / insulin like growth factor binding protein 4 / P22692
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.2
Gene start: 40443461
Gene end: 40457731
  
Corresponding Affymetrix probe sets: 201508_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000269593
NCBI entrez gene - 3487     See in Manteia.
OMIM - 146733
RefSeq - NM_001552
RefSeq Peptide - NP_001543
swissprot - A0A024R1U8
swissprot - P22692
Ensembl - ENSG00000141753
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGFBP4ENSGALG00000040672Gallus gallus
 Igfbp4ENSMUSG00000017493Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGFBP5 / P24593 / insulin like growth factor binding protein 5ENSG0000011546138
IGFBP2 / P18065 / insulin like growth factor binding protein 2ENSG0000011545737
IGFBP3 / P17936 / insulin like growth factor binding protein 3ENSG0000014667433
IGFBP1 / P08833 / insulin like growth factor binding protein 1ENSG0000014667831
IGFBP6 / P24592 / insulin like growth factor binding protein 6ENSG0000016777930


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata
 IPR022327  Insulin-like growth factor-binding protein 4
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0006259 DNA metabolic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway IBA
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0044342 type B pancreatic cell proliferation IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IBA
 molecular_functionGO:0031995 insulin-like growth factor II binding IBA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / complex / reaction
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / complex / reaction
 ENSG00000182752 PAPPA / Q13219 / pappalysin 1  / reaction
 ENSG00000116183 PAPPA2 / Q9BXP8 / pappalysin 2  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr