ENSG00000167779


Homo sapiens

Features
Gene ID: ENSG00000167779
  
Biological name :IGFBP6
  
Synonyms : IGFBP6 / insulin like growth factor binding protein 6 / P24592
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 53097436
Gene end: 53102345
  
Corresponding Affymetrix probe sets: 203851_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000301464
Ensembl peptide - ENSP00000448953
Ensembl peptide - ENSP00000449344
NCBI entrez gene - 3489     See in Manteia.
OMIM - 146735
RefSeq - XM_017019264
RefSeq - NM_002178
RefSeq Peptide - NP_002169
swissprot - F8VVA5
swissprot - P24592
swissprot - F8VYK9
Ensembl - ENSG00000167779
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp6aENSDARG00000070941Danio rerio
 igfbp6bENSDARG00000090833Danio rerio
 Igfbp6ENSMUSG00000023046Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGFBP3 / P17936 / insulin like growth factor binding protein 3ENSG0000014667436
IGFBP5 / P24593 / insulin like growth factor binding protein 5ENSG0000011546136
IGFBP2 / P18065 / insulin like growth factor binding protein 2ENSG0000011545735
IGFBP4 / P22692 / insulin like growth factor binding protein 4ENSG0000014175332
IGFBP1 / P08833 / insulin like growth factor binding protein 1ENSG0000014667827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata
 IPR022326  Insulin-like growth factor-binding protein 6
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway IBA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0042568 insulin-like growth factor binary complex IMP
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA
 molecular_functionGO:0031995 insulin-like growth factor II binding IMP


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / reaction / complex
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / reaction / complex






 

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