ENSG00000115457


Homo sapiens

Features
Gene ID: ENSG00000115457
  
Biological name :IGFBP2
  
Synonyms : IGFBP2 / insulin like growth factor binding protein 2 / P18065
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q35
Gene start: 216632828
Gene end: 216664436
  
Corresponding Affymetrix probe sets: 202718_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400308
Ensembl peptide - ENSP00000401698
Ensembl peptide - ENSP00000233809
Ensembl peptide - ENSP00000389646
NCBI entrez gene - 3485     See in Manteia.
OMIM - 146731
RefSeq - NM_000597
RefSeq - NM_001313990
RefSeq - NM_001313992
RefSeq - NM_001313993
RefSeq Peptide - NP_001300921
RefSeq Peptide - NP_001300922
RefSeq Peptide - NP_000588
RefSeq Peptide - NP_001300919
swissprot - C9JMY1
swissprot - C9JW52
swissprot - P18065
swissprot - H7C1H0
Ensembl - ENSG00000115457
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp2bENSDARG00000031422Danio rerio
 Q9PTH3ENSDARG00000052470Danio rerio
 IGFBP2ENSGALG00000011469Gallus gallus
 Igfbp2ENSMUSG00000039323Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGFBP4 / P22692 / insulin like growth factor binding protein 4ENSG0000014175330
IGFBP3 / P17936 / insulin like growth factor binding protein 3ENSG0000014667427
IGFBP5 / P24593 / insulin like growth factor binding protein 5ENSG0000011546126
IGFBP6 / P24592 / insulin like growth factor binding protein 6ENSG0000016777926
IGFBP1 / P08833 / insulin like growth factor binding protein 1ENSG0000014667826


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR012210  Insulin-like growth factor binding protein 2
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032868 response to insulin ISS
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway ISS
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA
 molecular_functionGO:0031995 insulin-like growth factor II binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / reaction / complex
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / reaction / complex






 

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