Manteia

ENSMUSG00000039323

Mus musculus

Features

Gene ID:	ENSMUSG00000039323

Biological name :	Igfbp2

Synonyms :	Igfbp2 / Insulin-like growth factor-binding protein 2 / P47877

Possible biological names infered from orthology :	P18065

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	C3
Gene start:	72824503
Gene end:	72852474

Corresponding Affymetrix probe sets:	10347277 (MoGene1.0st) 1454159_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000046610 Ensembl peptide - ENSMUSP00000112706 NCBI entrez gene - 16008 See in Manteia. MGI - MGI:96437 RefSeq - NM_001310659 RefSeq - NM_008342 RefSeq Peptide - NP_001297588 RefSeq Peptide - NP_032368 swissprot - P47877 swissprot - D3YU40 Ensembl - ENSMUSG00000039323

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Igfbp4 / P47879 / Insulin-like growth factor-binding protein 4 / P22692*	ENSMUSG00000017493	30
Igfbp1 / P47876 / Insulin-like growth factor-binding protein 1 / P08833*	ENSMUSG00000020429	30
Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*	ENSMUSG00000020427	29
Igfbp5 / Q07079 / Insulin-like growth factor-binding protein 5 / P24593*	ENSMUSG00000026185	27
Igfbp6 / P47880 / Insulin-like growth factor-binding protein 6 / P24592*	ENSMUSG00000023046	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR000716	Thyroglobulin type-1
IPR000867	Insulin-like growth factor-binding protein, IGFBP
IPR009030	Growth factor receptor cysteine-rich domain superfamily
IPR009168	Insulin-like growth factor binding protein
IPR012210	Insulin-like growth factor binding protein 2
IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata
IPR036857	Thyroglobulin type-1 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001558	regulation of cell growth	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007565	female pregnancy	IEA
biological_process	GO:0007568	aging	IEA
biological_process	GO:0007584	response to nutrient	IEA
biological_process	GO:0009612	response to mechanical stimulus	IEA
biological_process	GO:0010226	response to lithium ion	IEA
biological_process	GO:0032355	response to estradiol	IEA
biological_process	GO:0032526	response to retinoic acid	IEA
biological_process	GO:0032870	cellular response to hormone stimulus	IEA
biological_process	GO:0040008	regulation of growth	IEA
biological_process	GO:0042104	positive regulation of activated T cell proliferation	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	ISS
biological_process	GO:0043627	response to estrogen	IEA
biological_process	GO:0048545	response to steroid hormone	IEA
biological_process	GO:0051384	response to glucocorticoid	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0016324	apical plasma membrane	IEA
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
molecular_function	GO:0005520	insulin-like growth factor binding	IEA
molecular_function	GO:0019838	growth factor binding	IEA
molecular_function	GO:0031994	insulin-like growth factor I binding	IEA
molecular_function	GO:0031995	insulin-like growth factor II binding	IEA

Pathways (from Reactome)

Pathway description

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv,Casp6^tm1Flv/Casp6^tm1Flv Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Itk^tm1Lex/Itk^tm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv,Casp6^tm1Flv/Casp6^tm1Flv Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv,Casp6^tm1Flv/Casp6^tm1Flv Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0003918	decreased kidney weight	"reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv,Casp6^tm1Flv/Casp6^tm1Flv Genetic Background: involves: 129S1/Sv * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000048583	Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*	/ reaction / complex
ENSMUSG00000020053	Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*	/ reaction / complex

1 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr