ENSMUSG00000048583


Mus musculus

Features
Gene ID: ENSMUSG00000048583
  
Biological name :Igf2
  
Synonyms : Igf2 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P09535
  
Possible biological names infered from orthology : insulin like growth factor 2 / P01344
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 142650766
Gene end: 142666816
  
Corresponding Affymetrix probe sets: 10569344 (MoGene1.0st)   10569356 (MoGene1.0st)   1415931_at (Mouse Genome 430 2.0 Array)   1448152_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136786
Ensembl peptide - ENSMUSP00000114076
Ensembl peptide - ENSMUSP00000122653
Ensembl peptide - ENSMUSP00000000033
Ensembl peptide - ENSMUSP00000095549
Ensembl peptide - ENSMUSP00000101555
Ensembl peptide - ENSMUSP00000101556
NCBI entrez gene - 16002     See in Manteia.
MGI - MGI:96434
RefSeq - XM_006508487
RefSeq - NM_001122736
RefSeq - NM_001122737
RefSeq - NM_001315488
RefSeq - NM_001315489
RefSeq - NM_010514
RefSeq Peptide - NP_001302418
RefSeq Peptide - NP_034644
RefSeq Peptide - NP_001116209
RefSeq Peptide - NP_001116208
RefSeq Peptide - NP_001302417
swissprot - P09535
swissprot - J3QJZ9
swissprot - D3Z4N4
Ensembl - ENSMUSG00000048583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igf2aENSDARG00000018643Danio rerio
 igf2bENSDARG00000033307Danio rerio
 IGF2ENSGALG00000035282Gallus gallus
 IGF2ENSG00000167244Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*ENSMUSG0000002005327


Protein motifs (from Interpro)
Interpro ID Name
 IPR013576  Insulin-like growth factor II E-peptide, C-terminal
 IPR016179  Insulin-like
 IPR022334  Insulin-like growth factor II
 IPR022350  Insulin-like growth factor
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site
 IPR036438  Insulin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IEP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0031056 regulation of histone modification IMP
 biological_processGO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase IMP
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042104 positive regulation of activated T cell proliferation ISO
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IMP
 biological_processGO:0045840 positive regulation of mitotic nuclear division ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0051146 striated muscle cell differentiation IGI
 biological_processGO:0051147 regulation of muscle cell differentiation IMP
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0060669 embryonic placenta morphogenesis IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:2000467 positive regulation of glycogen (starch) synthase activity IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005158 insulin receptor binding ISO
 molecular_functionGO:0005159 insulin-like growth factor receptor binding ISO
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity ISO
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IMP
 molecular_functionGO:0048018 receptor ligand activity IMP


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Nodaltm1Mku/Nodaltm1Mku,Mesp1tm2(cre)Ysa/Mesp1+,Tg(Pitx2-lacZ)1Mbf/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nodaltm1Mku/Nodaltm1Mku,Mesp1tm2(cre)Ysa/Mesp1+,Tg(Pitx2-lacZ)1Mbf/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nodaltm1Mku/Nodaltm1Mku,Mesp1tm2(cre)Ysa/Mesp1+,Tg(Pitx2-lacZ)1Mbf/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Rr27tm1Tilg/Rr27+,Igf2tm1Rob/Igf2+,Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbp4tm1.1Mma/Rbp4tm1.1Mma
Genetic Background: involves: 129 * C57BL/6J

 MP:0001238 thin epidermal spinous layer "reduced thickness of the stratum spinosum; the polyhedral cell layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:15108]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mesttm1Masu/Mest+
Genetic Background: Not Specified

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk

Allelic Composition: Igf2tm3Wrk/Igf2+
Genetic Background: Not Specified

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Rbp4tm1.1Mma/Rbp4tm1.1Mma
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Mku/Nodaltm1Mku,Mesp1tm2(cre)Ysa/Mesp1+,Tg(Pitx2-lacZ)1Mbf/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2J

Allelic Composition: Igf2tm2Wrk/Igf2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Igf2tm3Wrk/Igf2+
Genetic Background: Not Specified

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Gpc3tm1Arge/Gpc3+,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Gpc3tm1Arge/Y,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv

 MP:0003787 abnormal imprinting "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rhbdf2tm1.1Mfm/Rhbdf2tm1.1Mfm
Genetic Background: B6.129S-Rhbdf2tm1.1Mfm

Allelic Composition: Igf2tm1Rob/Igf2tm4.1Wrk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003956 abnormal body size "anomaly in the average body weight, height and/or length of an organism compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpc3tm1Arge/Gpc3+,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Gpc3tm1Arge/Y,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0004196 abnormal prenatal growth/weight/body size "limited or accelerated growth or development apparent before birth" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0004265 abnormal placental transport "anomaly in the conveyance of metabolic products and nutrients across the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004920 increased placenta weight "increase in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm1Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0009265 delayed eyelid fusion "later than average time of the joining of the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm1Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009432 increased fetal weight "increase in the weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Rr27tm1Tilg/Rr27+,Igf2tm1Rob/Igf2+,Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0009673 increased birth weight "increase in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Igf2tm4Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010591 enlarged aortic valve "an increase in the total area occupied by the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010594 thick aortic valve "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010600 enlarged pulmonary valve "an increase in the total area occupied by the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010865 prenatal growth retardation "slow or limited development during the prenatal period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2tm4Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0010970 abnormal compact bone lamellar structure "any structural anomaly of the concentric layers of calcified matrix interspersed with osteocytes lodged in lacunae between the lamellae that comprise the cylindrical osteons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2tm1Snha/Igf2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf2tm1Rob/Igf2+
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Allelic Composition: Rr27tm1Tilg/Rr27+,Igf2tm1Rob/Igf2+,Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0012098 increased spongiotrophoblast size "greater size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm1Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0013309 adrenal gland cyst "presence of fluid-filled usually benign growths in the adrenal gland" [MGI:Anna]
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Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex / reaction
 ENSMUSG00000039323 Igfbp2 / P47877 / Insulin-like growth factor-binding protein 2 / P18065*  / reaction / complex
 ENSMUSG00000020427 Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex / reaction
 ENSMUSG00000054667 Irs4 / Q9Z0Y7 / Insulin receptor substrate 4 / O14654*  / complex / reaction
 ENSMUSG00000005533 Igf1r / insulin like growth factor 1 receptor / P08069*  / reaction / complex
 ENSMUSG00000040314 Ctsg / P28293 / cathepsin G / P08311*  / reaction
 ENSMUSG00000020429 Igfbp1 / P47876 / Insulin-like growth factor-binding protein 1 / P08833*  / complex / reaction
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / reaction
 ENSMUSG00000017493 Igfbp4 / P47879 / Insulin-like growth factor-binding protein 4 / P22692*  / complex / reaction
 ENSMUSG00000023046 Igfbp6 / P47880 / Insulin-like growth factor-binding protein 6 / P24592*  / reaction / complex
 ENSMUSG00000026185 Igfbp5 / Q07079 / Insulin-like growth factor-binding protein 5 / P24593*  / complex / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000031740 Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*  / reaction
 ENSMUSG00000046070 Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction / complex
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction
 ENSMUSG00000028370 Pappa / Q8R4K8 / Pappalysin-1 / Q13219*  / reaction
 ENSMUSG00000073530 Pappa2 / pappalysin 2 / Q9BXP8*  / reaction






 

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