ENSMUSG00000038894


Mus musculus

Features
Gene ID: ENSMUSG00000038894
  
Biological name :Irs2
  
Synonyms : Insulin receptor substrate 2 / Irs2 / P81122
  
Possible biological names infered from orthology : Q9Y4H2
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 10984681
Gene end: 11008458
  
Corresponding Affymetrix probe sets: 10576971 (MoGene1.0st)   1443969_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038514
NCBI entrez gene - 384783     See in Manteia.
MGI - MGI:109334
RefSeq - NM_001081212
RefSeq Peptide - NP_001074681
swissprot - P81122
Ensembl - ENSMUSG00000038894
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irs2aENSDARG00000037099Danio rerio
 irs2bENSDARG00000075282Danio rerio
 IRS2ENSGALG00000026287Gallus gallus
 IRS2ENSG00000185950Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irs1 / insulin receptor substrate 1 / P35568*ENSMUSG0000005598037
Irs4 / Q9Z0Y7 / Insulin receptor substrate 4 / O14654*ENSMUSG0000005466723
Irs3ENSMUSG0000004718213


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IGI
 biological_processGO:0002903 negative regulation of B cell apoptotic process IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0009749 response to glucose IDA
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IEA
 biological_processGO:0010907 positive regulation of glucose metabolic process IEA
 biological_processGO:0019216 regulation of lipid metabolic process IBA
 biological_processGO:0030335 positive regulation of cell migration IGI
 biological_processGO:0030879 mammary gland development IGI
 biological_processGO:0030890 positive regulation of B cell proliferation IDA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IEA
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033673 negative regulation of kinase activity IMP
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:1901653 cellular response to peptide IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
IRS-related events triggered by IGF1R
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA * FVB

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gsk3btm2Jrw/Gsk3btm2Jrw,Irs2tm1Mfw/Irs2tm1Mfw,Tg(Ins2-cre)23Herr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Ins2-cre)25Mgn/0,Tg(Ins2-Irs2)13Mfw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: am-J/a
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001377 abnormal copulation "reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Jos/Irs1+,Irs2tm2Mfw/Irs2tm2Mfw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Insrtm1Dac/Insr+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Tg(Ins2-Irs2)13Mfw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gsk3btm2Jrw/Gsk3btm2Jrw,Irs2tm1Mfw/Irs2tm1Mfw,Tg(Ins2-cre)23Herr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Irs1tm1Mfw/Irs1tm2.1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs1tm2.1Mfw/Irs1tm2.1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Whb/Foxo1+,Insrtm1Dac/Insrtm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Jos/Irs1+,Irs2tm2Mfw/Irs2tm2Mfw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003970 abnormal prolactin level 
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Irs2tm2Tka/Irs2tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka,Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs1tm1Jos/Irs1+,Irs2tm2Mfw/Irs2tm2Mfw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Tg(Ins2-Irs2)13Mfw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs1tm1Mfw/Irs1tm2.1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs1tm1Mfw/Irs1+,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs1tm2.1Mfw/Irs1tm2.1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Irs2tm2Tka/Irs2tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Irs1tm1Mfw/Irs1tm2.1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005448 abnormal energy balance "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008335 decreased gonadotroph cell number "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008368 small pituitary intermediate lobe "reduced size of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009174 absent pancreatic beta cells "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
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Allelic Composition: Insrtm1Dac/Insr+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Irs2tm2Tka/Irs2tm2Tka,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009433 polyovular ovarian follicle "an ovarian follicle containing more than one oocyte (ovum)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0009488 pancreatic islet cell apoptosis "change in the timing or the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Irs2tm1With/Irs2tm1With,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011819 increased pancreatic beta cell proliferation "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0020234 decreased basal metabolism "decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [GOC:NV]
Show

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / reaction / complex
 ENSMUSG00000003882 Il7r / P16872 / Interleukin-7 receptor subunit alpha / P16871* / interleukin 7 receptor*  / complex
 ENSMUSG00000005533 Igf1r / insulin like growth factor 1 receptor / P08069*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000057722 Lepr / P48356 / Leptin receptor / P48357*  / reaction / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000035804 Ins1 / P01325 / Insulin-1 Insulin-1 B chain Insulin-1 A chain / INS* / P01308* / insulin*  / reaction / complex
 ENSMUSG00000005534 Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*  / reaction / complex
 ENSMUSG00000000215 Ins2 / P01326 / Insulin-2 Insulin-2 B chain Insulin-2 A chain / INS* / P01308* / insulin*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / reaction / complex
 ENSMUSG00000059201 Lep / P41160 / Leptin / P41159*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000030733 Sh2b1 / Q91ZM2 / SH2B adapter protein 1 / Q9NRF2* / SH2B adaptor protein 1*  / reaction / complex
 ENSMUSG00000028072 Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*  / complex / reaction
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000040329 Il7 / P10168 / Interleukin-7 / P13232*  / complex






 

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