ENSDARG00000037099


Danio rerio

Features
Gene ID: ENSDARG00000037099
  
Biological name :irs2a
  
Synonyms : insulin receptor substrate 2a / irs2a
  
Possible biological names infered from orthology : insulin receptor substrate 2 / IRS2 / Irs3 / P81122 / Q9Y4H2
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 29211540
Gene end: 29228393
  
Corresponding Affymetrix probe sets: Dr.17415.1.S1_at (Zebrafish Array)   NM_200315_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000053923
NCBI entrez gene - 393285     See in Manteia.
RefSeq - NM_200315
RefSeq Peptide - NP_956609
swissprot - F1QHL0
ZFIN ID - ZDB-GENE-040426-975
Ensembl - ENSDARG00000037099
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRS2ENSGALG00000026287Gallus gallus
 IRS2ENSG00000185950Homo sapiens
 Irs2ENSMUSG00000038894Mus musculus
 Irs3ENSMUSG00000047182Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*ENSDARG0000007528263
irs1 / insulin receptor substrate 1 / P35568*ENSDARG0000005408742
irs4a / insulin receptor substrate 4aENSDARG0000008655133
si:ch73-335l21.1ENSDARG0000003641433
si:ch211-284e13.4ENSDARG0000006033030


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008286 insulin receptor signaling pathway IBA
 biological_processGO:0019216 regulation of lipid metabolic process IBA
 biological_processGO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005158 insulin receptor binding IBA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IBA


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
IRS-related events triggered by IGF1R
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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