ENSGALG00000026287


Gallus gallus

Features
Gene ID: ENSGALG00000026287
  
Biological name :IRS2
  
Synonyms : insulin receptor substrate 2 / IRS2
  
Possible biological names infered from orthology : Irs3 / P81122 / Q9Y4H2
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 138649358
Gene end: 138653145
  
Corresponding Affymetrix probe sets: GgaAffx.10780.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044008
Ensembl peptide - ENSGALP00000045027
Ensembl peptide - ENSGALP00000050607
Ensembl peptide - ENSGALP00000041049
swissprot - R4GG86
swissprot - A0A1D5NXD2
swissprot - A0A1D5PCW6
swissprot - A0A1D5NUJ0
Ensembl - ENSGALG00000026287
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irs2aENSDARG00000037099Danio rerio
 irs2bENSDARG00000075282Danio rerio
 IRS2ENSG00000185950Homo sapiens
 Irs2ENSMUSG00000038894Mus musculus
 Irs3ENSMUSG00000047182Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000000810741
IRS1 / insulin receptor substrate 1 / P35568*ENSGALG0000000495935


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IEA
 biological_processGO:0010907 positive regulation of glucose metabolic process IEA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0046326 positive regulation of glucose import IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
IRS-related events triggered by IGF1R
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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