ENSGALG00000004959


Gallus gallus

Features
Gene ID: ENSGALG00000004959
  
Biological name :IRS1
  
Synonyms : insulin receptor substrate 1 / IRS1
  
Possible biological names infered from orthology : P35568
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 9244127
Gene end: 9248424
  
Corresponding Affymetrix probe sets: GgaAffx.3088.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007937
swissprot - F1NIJ3
Ensembl - ENSGALG00000004959
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irs1ENSDARG00000054087Danio rerio
 IRS1ENSG00000169047Homo sapiens
 Irs1ENSMUSG00000055980Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRS2 / insulin receptor substrate 2 / Irs3* / P81122* / Q9Y4H2*ENSGALG0000002628743
ENSGALG0000000810740


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0010907 positive regulation of glucose metabolic process IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0019216 regulation of lipid metabolic process IBA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
IRS-related events triggered by IGF1R
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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