ENSMUSG00000055980


Mus musculus

Features
Gene ID: ENSMUSG00000055980
  
Biological name :Irs1
  
Synonyms : insulin receptor substrate 1 / Irs1
  
Possible biological names infered from orthology : P35568
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 82233101
Gene end: 82291416
  
Corresponding Affymetrix probe sets: 10356084 (MoGene1.0st)   1423104_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063795
NCBI entrez gene - 16367     See in Manteia.
MGI - MGI:99454
RefSeq - NM_010570
RefSeq Peptide - NP_034700
swissprot - Q543V3
Ensembl - ENSMUSG00000055980
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irs1ENSDARG00000054087Danio rerio
 IRS1ENSGALG00000004959Gallus gallus
 IRS1ENSG00000169047Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*ENSMUSG0000003889440
Irs4 / Q9Z0Y7 / Insulin receptor substrate 4 / O14654*ENSMUSG0000005466724
Irs3ENSMUSG0000004718214


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0010907 positive regulation of glucose metabolic process IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
IRS-related events triggered by IGF1R
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs1tm3.1Mfw/Irs1tm3.1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

Allelic Composition: Irs1Sml/Irs1+
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

Allelic Composition: Irs1mpc178H/Irs1mpc178H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxn1nu/Foxn1nu,Ivltm1Dji/Ivltm1Dji
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA * FVB

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu/Foxn1nu,Ivltm1Dji/Ivltm1Dji
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

Allelic Composition: Irs1Sml/Irs1+
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0000589 thin tail "a tail with a smaller diameter than the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: C57BL/6

Allelic Composition: Irs1tm2.1Mfw/Irs1tm2.1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Irs1tm1Jos/Irs1+,Irs2tm2Mfw/Irs2tm2Mfw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Irs1tm3.1Mfw/Irs1tm3.1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Irs1tm2.1Mfw/Irs1tm2.1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

Allelic Composition: Irs1Sml/Irs1+
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

Allelic Composition: Irs1smla/Irs1smla
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Jos/Irs1+,Irs2tm2Mfw/Irs2tm2Mfw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Y
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Irs4tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Irs1mpc178H/Irs1mpc178H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka,Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Y
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Irs4tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Irs1tm2.1Mfw/Irs1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Irs1tm2.1Mfw/Irs1tm2.1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Irs1tm1Mfw/Irs1tm2.1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs1tm2.1Mfw/Irs1tm2.1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

Allelic Composition: Irs1Sml/Irs1+
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

Allelic Composition: Irs1smla/Irs1smla
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

Allelic Composition: Irs1smla/Irs1smla
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrm2tm1Jwe/Chrm2tm1Jwe,Chrm4tm1Jwe/Chrm4tm1Jwe
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * CF-1

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Jos/Irs1+,Irs2tm2Mfw/Irs2tm2Mfw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

Allelic Composition: Irs1Sml/Irs1+
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0003795 abnormal bone structure 
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Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Irs2tm2Tka/Irs2tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka,Irs2tm1Tka/Irs2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs1tm1Jos/Irs1+,Irs2tm2Mfw/Irs2tm2Mfw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irs1tm2.1Mfw/Irs1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Irs1tm2.1Mfw/Irs1tm2.1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Y
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Irs4tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs1tm2.1Mfw/Irs1tm2.1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Irs1tm1Mfw/Irs1tm2.1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs1tm1Mfw/Irs1+,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs1tm2.1Mfw/Irs1tm2.1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Y
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Irs4tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Irs2tm2Tka/Irs2tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Irs1tm2.1Mfw/Irs1tm2.1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Irs1tm1Mfw/Irs1tm2.1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

Allelic Composition: Irs1Sml/Irs1+
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1Sml/Irs1+
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0011711 decreased osteoblast differentiation 
Show

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0030439 decreased osteoblast proliferation "reduction in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
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Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / complex / reaction
 ENSMUSG00000003882 Il7r / P16872 / Interleukin-7 receptor subunit alpha / P16871* / interleukin 7 receptor*  / complex
 ENSMUSG00000005533 Igf1r / insulin like growth factor 1 receptor / P08069*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000028072 Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*  / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000035804 Ins1 / P01325 / Insulin-1 Insulin-1 B chain Insulin-1 A chain / INS* / P01308* / insulin*  / reaction / complex
 ENSMUSG00000000215 Ins2 / P01326 / Insulin-2 Insulin-2 B chain Insulin-2 A chain / INS* / P01308* / insulin*  / complex / reaction
 ENSMUSG00000005534 Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*  / complex / reaction
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000040329 Il7 / P10168 / Interleukin-7 / P13232*  / complex






 

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