Manteia

ENSG00000169047

Homo sapiens

Features

Gene ID:	ENSG00000169047

Biological name :	IRS1

Synonyms :	insulin receptor substrate 1 / IRS1 / P35568

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	2
Strand:	-1
Band:	q36.3
Gene start:	226731317
Gene end:	226799759

Corresponding Affymetrix probe sets:	204686_at (Human Genome U133 Plus 2.0 Array) 238933_at (Human Genome U133 Plus 2.0 Array) 242979_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000304895 NCBI entrez gene - 3667 See in Manteia. OMIM - 147545 RefSeq - NM_005544 RefSeq Peptide - NP_005535 swissprot - A0A024R499 swissprot - P35568 Ensembl - ENSG00000169047

Related genetic diseases (OMIM):	125853 - {Diabetes mellitus, noninsulin-dependent}, 125853
	147545 - {Coronary artery disease, susceptibility to}

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
irs1	ENSDARG00000054087	Danio rerio
IRS1	ENSGALG00000004959	Gallus gallus
Irs1	ENSMUSG00000055980	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
IRS2 / Q9Y4H2 / insulin receptor substrate 2	ENSG00000185950	41
IRS4 / O14654 / insulin receptor substrate 4	ENSG00000133124	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR001849	Pleckstrin homology domain
IPR002404	IRS-type PTB domain
IPR011993	PH-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	TAS
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0008284	positive regulation of cell proliferation	NAS
biological_process	GO:0008286	insulin receptor signaling pathway	IMP
biological_process	GO:0010907	positive regulation of glucose metabolic process	IMP
biological_process	GO:0014065	phosphatidylinositol 3-kinase signaling	IDA
biological_process	GO:0032000	positive regulation of fatty acid beta-oxidation	IMP
biological_process	GO:0032868	response to insulin	IDA
biological_process	GO:0032869	cellular response to insulin stimulus	IMP
biological_process	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	IEA
biological_process	GO:0038111	interleukin-7-mediated signaling pathway	TAS
biological_process	GO:0042593	glucose homeostasis	TAS
biological_process	GO:0043434	response to peptide hormone	ISS
biological_process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISS
biological_process	GO:0045725	positive regulation of glycogen biosynthetic process	NAS
biological_process	GO:0046326	positive regulation of glucose import	IMP
biological_process	GO:0046627	negative regulation of insulin receptor signaling pathway	ISS
biological_process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISS
biological_process	GO:0046676	negative regulation of insulin secretion	IDA
biological_process	GO:0046854	phosphatidylinositol phosphorylation	IEA
biological_process	GO:0048009	insulin-like growth factor receptor signaling pathway	IPI
biological_process	GO:0048015	phosphatidylinositol-mediated signaling	TAS
biological_process	GO:0051897	positive regulation of protein kinase B signaling	TAS
biological_process	GO:2001275	positive regulation of glucose import in response to insulin stimulus	IDA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005737	cytoplasm	TAS
cellular_component	GO:0005829	cytosol	IBA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005899	insulin receptor complex	ISS
cellular_component	GO:0005901	caveola	IDA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	ISS
molecular_function	GO:0001784	phosphotyrosine residue binding	IPI
molecular_function	GO:0004871	obsolete signal transducer activity	TAS
molecular_function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	TAS
molecular_function	GO:0005080	protein kinase C binding	ISS
molecular_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity	TAS
molecular_function	GO:0005158	insulin receptor binding	IPI
molecular_function	GO:0005159	insulin-like growth factor receptor binding	IPI
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016303	1-phosphatidylinositol-3-kinase activity	TAS
molecular_function	GO:0042169	SH2 domain binding	ISS
molecular_function	GO:0043548	phosphatidylinositol 3-kinase binding	ISS
molecular_function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS

Pathways (from Reactome)

Pathway description

PI3K Cascade

IRS-mediated signalling

SOS-mediated signalling

PIP3 activates AKT signaling

Interleukin-7 signaling

PI3K/AKT activation

Constitutive Signaling by Aberrant PI3K in Cancer

IRS-related events triggered by IGF1R

Signaling by Leptin

RAF/MAP kinase cascade

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

IRS activation

Signal attenuation

Activated NTRK3 signals through PI3K

Growth hormone receptor signaling

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000105647	O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2	/ reaction / complex
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ complex / reaction
ENSG00000102882	MAPK3 / P27361 / mitogen-activated protein kinase 3	/ reaction
ENSG00000017427	IGF1 / P05019 / insulin like growth factor 1	/ reaction / complex
ENSG00000174697	LEP / leptin / P41159	/ reaction / complex
ENSG00000140443	IGF1R / P08069 / insulin like growth factor 1 receptor	/ complex / reaction
ENSG00000051382	P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	/ complex / reaction
ENSG00000254647	INS / P01308 / insulin	/ reaction / complex
ENSG00000105639	JAK3 / P52333 / Janus kinase 3	/ complex
ENSG00000104432	IL7 / P13232 / interleukin 7	/ complex
ENSG00000169047	IRS1 / P35568 / insulin receptor substrate 1	/ complex / reaction
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ reaction / complex
ENSG00000168685	IL7R / P16871 / interleukin 7 receptor	/ complex
ENSG00000213281	NRAS / P01111 / NRAS proto-oncogene, GTPase	/ reaction
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ complex / reaction
ENSG00000178188	SH2B1 / Q9NRF2 / SH2B adaptor protein 1	/ complex / reaction
ENSG00000096968	JAK2 / O60674 / Janus kinase 2	/ complex / reaction
ENSG00000198400	NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1	/ reaction / complex
ENSG00000171105	INSR / P06213 / insulin receptor	/ complex / reaction
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ reaction / complex
ENSG00000185950	IRS2 / Q9Y4H2 / insulin receptor substrate 2	/ complex / reaction
ENSG00000147168	IL2RG / P31785 / interleukin 2 receptor subunit gamma	/ complex
ENSG00000134259	NGF / P01138 / nerve growth factor	/ complex / reaction
ENSG00000133703	KRAS / P01116 / KRAS proto-oncogene, GTPase	/ reaction
ENSG00000116678	LEPR / P48357 / leptin receptor	/ complex / reaction
ENSG00000174775	HRAS / P01112 / HRas proto-oncogene, GTPase	/ reaction
ENSG00000162434	JAK1 / P23458 / Janus kinase 1	/ complex
ENSG00000167244	IGF2 / P01344 / insulin like growth factor 2	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr