ENSG00000133124


Homo sapiens

Features
Gene ID: ENSG00000133124
  
Biological name :IRS4
  
Synonyms : insulin receptor substrate 4 / IRS4 / O14654
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q22.3
Gene start: 108732482
Gene end: 108736409
  
Corresponding Affymetrix probe sets: 207403_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361202
NCBI entrez gene - 8471     See in Manteia.
OMIM - 300904
RefSeq - NM_003604
RefSeq Peptide - NP_003595
swissprot - O14654
Ensembl - ENSG00000133124
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Irs4ENSMUSG00000054667Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRS2 / Q9Y4H2 / insulin receptor substrate 2ENSG0000018595026
IRS1 / P35568 / insulin receptor substrate 1ENSG0000016904725


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008286 insulin receptor signaling pathway IBA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0019216 regulation of lipid metabolic process IBA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005158 insulin receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IBA


Pathways (from Reactome)
Pathway description
IRS-related events triggered by IGF1R


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / reaction / complex
 ENSG00000140443 IGF1R / P08069 / insulin like growth factor 1 receptor  / complex / reaction
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / reaction / complex






 

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contact: otassy@igbmc.fr