ENSG00000185950


Homo sapiens

Features
Gene ID: ENSG00000185950
  
Biological name :IRS2
  
Synonyms : insulin receptor substrate 2 / IRS2 / Q9Y4H2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q34
Gene start: 109752698
Gene end: 109786568
  
Corresponding Affymetrix probe sets: 209184_s_at (Human Genome U133 Plus 2.0 Array)   209185_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000365016
NCBI entrez gene - 8660     See in Manteia.
OMIM - 600797
RefSeq - NM_003749
RefSeq Peptide - NP_003740
swissprot - Q9Y4H2
Ensembl - ENSG00000185950
  
Related genetic diseases (OMIM): 125853 - {Diabetes mellitus, noninsulin-dependent}, 125853
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irs2aENSDARG00000037099Danio rerio
 irs2bENSDARG00000075282Danio rerio
 IRS2ENSGALG00000026287Gallus gallus
 Irs2ENSMUSG00000038894Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRS1 / P35568 / insulin receptor substrate 1ENSG0000016904738
IRS4 / O14654 / insulin receptor substrate 4ENSG0000013312424


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0002903 negative regulation of B cell apoptotic process IEA
 biological_processGO:0006006 glucose metabolic process TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IMP
 biological_processGO:0010907 positive regulation of glucose metabolic process IMP
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IMP
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0038111 interleukin-7-mediated signaling pathway TAS
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process NAS
 biological_processGO:0046326 positive regulation of glucose import IMP
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling TAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0055088 lipid homeostasis TAS
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:1901653 cellular response to peptide IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
Constitutive Signaling by Aberrant PI3K in Cancer
IRS-related events triggered by IGF1R
Signaling by Leptin
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
RET signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000187266 EPOR / P19235 / erythropoietin receptor  / complex
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000130427 EPO / P01588 / erythropoietin  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000141506 PIK3R5 / Q8WYR1 / phosphoinositide-3-kinase regulatory subunit 5  / reaction / complex
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / reaction / complex
 ENSG00000174697 LEP / leptin / P41159  / reaction / complex
 ENSG00000140443 IGF1R / P08069 / insulin like growth factor 1 receptor  / reaction / complex
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / reaction / complex
 ENSG00000169047 IRS1 / P35568 / insulin receptor substrate 1  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000178188 SH2B1 / Q9NRF2 / SH2B adaptor protein 1  / reaction / complex
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000105851 P48736 / PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma  / complex / reaction
 ENSG00000116678 LEPR / P48357 / leptin receptor  / reaction / complex
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / reaction / complex
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / reaction / complex
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / complex / reaction
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / complex
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000168685 IL7R / P16871 / interleukin 7 receptor  / complex
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction / complex
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / reaction / complex
 ENSG00000171105 INSR / P06213 / insulin receptor  / complex / reaction
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / complex
 ENSG00000254647 INS / P01308 / insulin  / reaction / complex
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000104432 IL7 / P13232 / interleukin 7  / complex






 

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