Manteia

ENSG00000126561

Homo sapiens

Features

Gene ID:	ENSG00000126561

Biological name :	STAT5A

Synonyms :	P42229 / signal transducer and activator of transcription 5A / STAT5A

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	17
Strand:	1
Band:	q21.2
Gene start:	42287547
Gene end:	42311943

Corresponding Affymetrix probe sets:	203010_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000466320 Ensembl peptide - ENSP00000465437 Ensembl peptide - ENSP00000468749 Ensembl peptide - ENSP00000341208 Ensembl peptide - ENSP00000407327 Ensembl peptide - ENSP00000443107 Ensembl peptide - ENSP00000464730 NCBI entrez gene - 6776 See in Manteia. OMIM - 601511 RefSeq - XM_005257624 RefSeq - NM_001288718 RefSeq - NM_001288719 RefSeq - NM_001288720 RefSeq - NM_003152 RefSeq Peptide - NP_001275649 RefSeq Peptide - NP_001275647 RefSeq Peptide - NP_001275648 RefSeq Peptide - NP_003143 swissprot - K7EM17 swissprot - K7EIF9 swissprot - P42229 swissprot - C9JVV6 swissprot - K7EK35 Ensembl - ENSG00000126561

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
stat5a	ENSDARG00000019392	Danio rerio
stat5b	ENSDARG00000055588	Danio rerio
STAT5B	ENSGALG00000003282	Gallus gallus
P42230	ENSMUSG00000004043	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P51692 / STAT5B / signal transducer and activator of transcription 5B	ENSG00000173757	92
STAT6 / P42226 / signal transducer and activator of transcription 6	ENSG00000166888	37
STAT4 / Q14765 / signal transducer and activator of transcription 4	ENSG00000138378	28
STAT1 / P42224 / signal transducer and activator of transcription 1	ENSG00000115415	28
STAT3 / P40763 / signal transducer and activator of transcription 3	ENSG00000168610	28
STAT2 / P52630 / signal transducer and activator of transcription 2	ENSG00000170581	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR000980	SH2 domain
IPR001217	Transcription factor STAT
IPR008967	p53-like transcription factor, DNA-binding
IPR012345	STAT transcription factor, DNA-binding, N-terminal
IPR013799	STAT transcription factor, protein interaction
IPR013800	STAT transcription factor, all-alpha domain
IPR013801	STAT transcription factor, DNA-binding
IPR015988	STAT transcription factor, coiled coil
IPR035858	STAT5a/5b
IPR036535	STAT transcription factor, N-terminal domain superfamily
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000255	allantoin metabolic process	ISS
biological_process	GO:0001938	positive regulation of endothelial cell proliferation	IMP
biological_process	GO:0006101	citrate metabolic process	ISS
biological_process	GO:0006103	2-oxoglutarate metabolic process	ISS
biological_process	GO:0006105	succinate metabolic process	ISS
biological_process	GO:0006107	oxaloacetate metabolic process	ISS
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	TAS
biological_process	GO:0006549	isoleucine metabolic process	ISS
biological_process	GO:0006573	valine metabolic process	ISS
biological_process	GO:0006600	creatine metabolic process	ISS
biological_process	GO:0006631	fatty acid metabolic process	ISS
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007259	JAK-STAT cascade	TAS
biological_process	GO:0007595	lactation	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0019221	cytokine-mediated signaling pathway	TAS
biological_process	GO:0019530	taurine metabolic process	ISS
biological_process	GO:0035723	interleukin-15-mediated signaling pathway	TAS
biological_process	GO:0038110	interleukin-2-mediated signaling pathway	TAS
biological_process	GO:0038111	interleukin-7-mediated signaling pathway	TAS
biological_process	GO:0040014	regulation of multicellular organism growth	ISS
biological_process	GO:0043536	positive regulation of blood vessel endothelial cell migration	IMP
biological_process	GO:0046449	creatinine metabolic process	ISS
biological_process	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IDA
molecular_function	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	NAS
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	TAS
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Prolactin receptor signaling

Nuclear signaling by ERBB4

Interleukin-7 signaling

Signaling by SCF-KIT

Signaling by cytosolic FGFR1 fusion mutants

Downstream signal transduction

Signaling by Leptin

Interleukin-3, Interleukin-5 and GM-CSF signaling

Interleukin-20 family signaling

Interleukin-15 signaling

Interleukin-9 signaling

Interleukin-2 signaling

Interleukin-21 signaling

Growth hormone receptor signaling

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000187266	EPOR / P19235 / erythropoietin receptor	/ reaction / complex
ENSG00000049130	KITLG / P21583 / KIT ligand	/ reaction / complex
ENSG00000111790	Q9NVK5 / FGFR1OP2 / FGFR1 oncogene partner 2	/ reaction
ENSG00000130427	EPO / P01588 / erythropoietin	/ complex / reaction
ENSG00000113525	IL5 / P05113 / interleukin 5	/ complex / reaction
ENSG00000112964	GHR / P10912 / growth hormone receptor	/ reaction / complex
ENSG00000113494	PRLR / P16471 / prolactin receptor	/ reaction / complex
ENSG00000091181	IL5RA / Q01344 / interleukin 5 receptor subunit alpha	/ reaction / complex
ENSG00000100368	CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit	/ reaction / complex
ENSG00000178568	ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4	/ complex / reaction
ENSG00000168610	STAT3 / P40763 / signal transducer and activator of transcription 3	/ complex / reaction
ENSG00000174697	LEP / leptin / P41159	/ complex / reaction
ENSG00000164399	IL3 / P08700 / interleukin 3	/ reaction / complex
ENSG00000164400	CSF2 / P04141 / colony stimulating factor 2	/ complex / reaction
ENSG00000257923	CUX1 / P39880 / Q13948 / cut like homeobox 1	/ reaction
ENSG00000186716	BCR / P11274 / BCR, RhoGEF and GTPase activating protein	/ reaction
ENSG00000172179	PRL / P01236 / prolactin	/ reaction / complex
ENSG00000157404	KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase	/ complex / reaction
ENSG00000259384	GH1 / P01241 / growth hormone 1	/ complex / reaction
ENSG00000136487	GH2 / P01242 / growth hormone 2	/ complex / reaction
ENSG00000136488	CSH1 / P0DML2 / chorionic somatomammotropin hormone 1	/ complex / reaction
ENSG00000185291	IL3RA / P26951 / interleukin 3 receptor subunit alpha	/ reaction / complex
ENSG00000198223	CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit	/ reaction / complex
ENSG00000116678	LEPR / P48357 / leptin receptor	/ reaction / complex
ENSG00000115415	STAT1 / P42224 / signal transducer and activator of transcription 1	/ complex / reaction
ENSG00000096968	JAK2 / O60674 / Janus kinase 2	/ complex / reaction
ENSG00000173757	P51692 / STAT5B / signal transducer and activator of transcription 5B	/ complex / reaction
ENSG00000126561	P42229 / STAT5A / signal transducer and activator of transcription 5A	/ reaction / complex
ENSG00000105639	JAK3 / P52333 / Janus kinase 3	/ complex / reaction
ENSG00000168685	IL7R / P16871 / interleukin 7 receptor	/ complex
ENSG00000147168	IL2RG / P31785 / interleukin 2 receptor subunit gamma	/ reaction / complex
ENSG00000124334	IL9R / Q01113 / interleukin 9 receptor	/ reaction / complex
ENSG00000162434	JAK1 / P23458 / Janus kinase 1	/ complex / reaction
ENSG00000104432	IL7 / P13232 / interleukin 7	/ complex
ENSG00000145839	IL9 / P15248 / interleukin 9	/ complex / reaction
ENSG00000121741	ZMYM2 / Q9UBW7 / zinc finger MYM-type containing 2	/ reaction
ENSG00000185950	IRS2 / Q9Y4H2 / insulin receptor substrate 2	/ reaction / complex
ENSG00000254087	LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr