ENSDARG00000019392


Danio rerio

Features
Gene ID: ENSDARG00000019392
  
Biological name :stat5a
  
Synonyms : signal transducer and activator of transcription 5a / stat5a
  
Possible biological names infered from orthology : P42229 / P42230 / P42232 / P51692 / signal transducer and activator of transcription 5B / STAT5B
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 17251542
Gene end: 17331919
  
Corresponding Affymetrix probe sets: Dr.15667.1.A1_at (Zebrafish Array)   NM_194387_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000022542
Ensembl peptide - ENSDARP00000120022
NCBI entrez gene - 369197     See in Manteia.
RefSeq - NM_194387
RefSeq Peptide - NP_919368
swissprot - F6NMQ4
swissprot - Q68SP3
ZFIN ID - ZDB-GENE-030820-2
Ensembl - ENSDARG00000019392
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STAT5BENSGALG00000003282Gallus gallus
 P42229ENSG00000126561Homo sapiens
 P51692ENSG00000173757Homo sapiens
 P42230ENSMUSG00000004043Mus musculus
 P42232ENSMUSG00000020919Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
stat5b / signal transducer and activator of transcription 5b / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*ENSDARG0000005558884
stat6 / signal transducer and activator of transcription 6, interleukin-4 induced / P42226* / P52633* / Signal transducer and transcription activator 6 * / signal transducer and activator o...ENSDARG0000001590233
stat3 / signal transducer and activator of transcription 3 (acute-phase response factor) / P40763* / P42227* / signal transducer and activator of transcription 3*ENSDARG0000002271229
stat4 / signal transducer and activator of transcription 4 / Q14765*ENSDARG0000002873128
stat1a / signal transducer and activator of transcription 1a / STAT1* / P42224* / signal transducer and activator of transcription 1*ENSDARG0000000626627
stat2 / signal transducer and activator of transcription 2 / P52630*ENSDARG0000003164726
stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*ENSDARG0000007618225


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007259 JAK-STAT cascade IMP
 biological_processGO:0030098 lymphocyte differentiation IMP
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Interleukin-7 signaling
Signaling by SCF-KIT
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
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 ZFA:0001078 thymus thymus decreased amount , abnormal
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 ZFA:0001462 somite border somite border shape , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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